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AB45164

Anti-Allopregnanolone antibody

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(1 Publication)

Rabbit Polyclonal Allopregnanolone antibody. Suitable for ELISA and reacts with Mouse, Rat, Pig, Chicken, Human, Goat, Rabbit samples. Cited in 1 publication. Immunogen corresponding to Chemical / Small Molecule corresponding to Allopregnanolone.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Rabbit, Goat, Chicken, Human, Pig

Applications

ELISA

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" }, "Mouse": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" }, "Rat": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" }, "Chicken": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" }, "Goat": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" }, "Pig": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" }, "Rabbit": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Allopregnanolone also known as 3α-hydroxy-5α-pregnan-20-one is a neurosteroid with a molecular mass of approximately 318.5 g/mol. It acts on the central nervous system primarily modulating gamma-aminobutyric acid type A (GABA-A) receptors. In the brain allopregnanolone serves as a potent inhibitory modulator by enhancing GABAergic signaling. Neurons in specific regions like the hippocampus and prefrontal cortex express this neurosteroid. Its interaction at receptor sites leads to various downstream effects important for neurologic function.
Biological function summary

Allopregnanolone significantly influences mood regulation anxiety and stress response. As a neuroactive steroid it is not part of a complex but interacts with GABA-A receptor complexes. Its modulation of GABA-A receptors contributes to its sedative anxiolytic and anticonvulsant properties. This neurosteroid plays a critical role in regulating the inhibitory tone in the central nervous system affecting psychological and behavioral states.

Pathways

This neurosteroid operates within the stress response and hormonal regulation pathways. Allopregnanolone interacts with the GABAergic signaling pathway influencing neurotransmission and neuronal excitability. The pregnane X receptor (PXR) and the GABA-A receptor form important links in these pathways illustrating how it modulates synaptic plasticity and resilience to stress. Through the regulation of these pathways allopregnanolone also indirectly affects other proteins like neurosteroidogenic enzymes.

Allopregnanolone has a connection with depression and epilepsy. Dysregulation of allopregnanolone levels associates with major depressive disorder impacting mood and stress responses. In epilepsy altered GABAergic activity can result in seizure susceptibility which allopregnanolone helps to modulate through its anticonvulsant properties. The protein GABA-A receptor plays an important role in these conditions where its altered function or expression correlates with the neurosteroid's efficacy in mitigating symptoms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Allopregnanolone
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 13:1566567 PubMed40213392

2025

Quantitation of global histone post-translational modifications reveal anti-inflammatory epigenetic mechanisms of liquiritigenin based on the optimized super-SILAC strategy.

Applications

Unspecified application

Species

Unspecified reactive species

Ping Liu,Jun Zhang,Jingdan Zhang,Yucheng Yuan,Zhiqing Liu,Sixian Chen,Kaifeng Chen,Li Dong,Zhiyuan Cheng,Yinan Zhang,Meiyu Geng,Minjia Tan,Wensi Zhao,Dong Xie
View all publications
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