AB239473

Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1]

Name: Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473) | Abcam
Brand: Abcam Limited
SKU: AB239473
Price: 525 USD
Availability: InStock

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(2 Publications)

Mouse Monoclonal A1AG antibody. Suitable for WB, IHC-P and reacts with Rat, Recombinant full length protein - Rat, Pig samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Rat Orm1 aa 1-200.

View Alternative Names

Alpha-1-acid glycoprotein, Orosomucoid, OMD, Orm1

8 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)

Paraffin-embedded rat liver tissue stained for Alpha 1 Acid Glycoprotein/AGP using ab239473 at 30 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)

Paraffin-embedded rat heart tissue stained for Alpha 1 Acid Glycoprotein/AGP using ab239473 at 30 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)

Paraffin-embedded rat stomach tissue stained for Alpha 1 Acid Glycoprotein/AGP using ab239473 at 30 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)

Paraffin-embedded rat adrenal gland tissue stained for Alpha 1 Acid Glycoprotein/AGP using ab239473 at 30 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)

All lanes:

Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473) at 2 µg/mL

All lanes:

Rat testis lysate

Predicted band size: 24 kDa

false

Supplier Data

Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)

All lanes:

Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473) at 2 µg/mL

Lane 1:

Rat brain lysate

Lane 2:

Rat cerebellum lysate

Lane 3:

Pig brain lysate

Secondary

All lanes:

HRP Linked Rabbit Anti-Mouse IgG at 1/5000 dilution

Predicted band size: 24 kDa

false

Supplier Data

Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)

All lanes:

Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473) at 2 µg/mL

All lanes:

Rat liver lysate

Predicted band size: 24 kDa

false

Supplier Data

Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)

All lanes:

Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473) at 2 µg/mL

All lanes:

Recombinant rat Alpha 1 Acid Glycoprotein/AGP protein

Secondary

All lanes:

HRP Linked Rabbit Anti-Mouse IgG at 1/5000 dilution

Predicted band size: 24 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

Isotype

IgG2b

Light chain type

kappa

Carrier free

Reacts with

Rat, Pig

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Rat Orm1 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

P02764

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-30 µg/mL", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "5-30 µg/mL", "IHCP-species-notes": "" }, "Recombinant full length protein - Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A/G

Purification notes

Purified from TCS.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Alpha 1 Acid Glycoprotein also known as AGP or Alpha 1 Glycoprotein is a plasma protein with a molecular weight of approximately 41 to 43 kDa. This protein circulates primarily in the bloodstream and is produced mainly by the liver. AGP is known for its highly glycosylated structure carrying several branched oligosaccharide chains. It exhibits a significant capacity to bind various endogenous and exogenous lipophilic substances influencing their transport and distribution in the body.

Biological function summary

AGP plays a role in modulating the immune response and maintaining homeostasis. As an acute-phase protein its levels rise significantly during inflammation infection and trauma where it acts to modulate the immune system. AGP does not exist as part of a larger protein complex but interacts with plasma lipoproteins and other glycoproteins aiding in its function of maintaining vascular integrity during acute-phase reactions.

Pathways

Alpha 1 Glycoprotein serves as an important component in the inflammatory response and drug-binding pathways. In the inflammatory pathway AGP interacts with cytokines and acute-phase reactants adjusting the body’s inflammatory processes. It is also involved in the binding and distribution of drugs interacting with albumin and other transport proteins to influence the pharmacokinetics of many medications.

AGP levels change in response to conditions like rheumatoid arthritis and liver diseases. In rheumatoid arthritis its increased levels correlate with disease activity and inflammation. In liver diseases the production and plasma concentration of AGP can reflect hepatic synthesis capability. AGP's interaction with cytokines in these conditions often links it to elevated levels of other acute-phase proteins like C-reactive protein reflecting its participation in the pathophysiological processes of inflammation.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Functions as a transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.

See full target information Orm1

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Respiratory research 24:83 PubMed36927357

2023

Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets.

Applications

Unspecified application

Species

Unspecified reactive species

Ana M Rodriguez-Piñeiro,Florian Jaudas,Nikolai Klymiuk,Andrea Bähr,Gunnar C Hansson,Anna Ermund

Cells 10: PubMed34571914

2021

Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Whitney F Alpaugh,Anna L Voigt,Rkia Dardari,Lin Su,Iman Al Khatib,Wisoo Shin,Taylor M Goldsmith,Krysta M Coyle,Lin A Tang,Timothy E Shutt,Claudia Klein,Jeff Biernaskie,Ina Dobrinski

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)

Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)

Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)

Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)

Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Carrier free

Reacts with

Applications

Immunogen

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Secondary Antibodies

Assay Kits

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Product promise