Mouse Monoclonal A1AG antibody. Suitable for WB, IHC-P and reacts with Rat, Recombinant full length protein - Rat, Pig samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Rat Orm1 aa 1-200.
Images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473), expandable thumbnail](https://content.abcam.com/products/images/alpha-1-acid-glycoprotein-agp-antibody-c1-ab239473--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img64837.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)")
![Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473), expandable thumbnail](https://content.abcam.com/products/images/alpha-1-acid-glycoprotein-agp-antibody-c1-ab239473--western-blot-img35973.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473), expandable thumbnail](https://content.abcam.com/products/images/alpha-1-acid-glycoprotein-agp-antibody-c1-ab239473--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img21862.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473), expandable thumbnail](https://content.abcam.com/products/images/alpha-1-acid-glycoprotein-agp-antibody-c1-ab239473--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img114732.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)")
![Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473), expandable thumbnail](https://content.abcam.com/products/images/alpha-1-acid-glycoprotein-agp-antibody-c1-ab239473--western-blot-img105057.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (AB239473)")
Publications
Filter by
- Respiratory research 24:832023Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAna M Rodriguez-Piñeiro,Florian Jaudas,Nikolai Klymiuk,Andrea Bähr,Gunnar C Hansson,Anna ErmundPubMed 36927357
Key facts
- Isotype
IgG2b
- Host species
Mouse
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 55.77% Glycerol (glycerin, glycerine), 44.12% PBS- Form
Liquid
- Clonality
Monoclonal
Immunogen
- Recombinant Fragment Protein within Rat Orm1 aa 1-200. The exact immunogen used to generate this antibody is proprietary information. Database link P02764
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Rat | Tested | Tested |
| Pig | Tested | Expected |
| Recombinant full length protein - Rat | Tested | Not recommended |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 0.5-5 µg/mL | Notes - |
Species Recombinant full length protein - Rat | Dilution info 0.5-5 µg/mL | Notes - |
Species Pig | Dilution info 0.5-5 µg/mL | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 5-30 µg/mL | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Pig | Dilution info 5-30 µg/mL | Notes - |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant full length protein - Rat | Dilution info - | Notes - |
Associated Products
Select an associated product type
3 products for Alternative Product
Target data
Function
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Alternative names
Alpha-1-acid glycoprotein, Orosomucoid, OMD, Orm1
Recommended products
Mouse Monoclonal A1AG antibody. Suitable for WB, IHC-P and reacts with Rat, Recombinant full length protein - Rat, Pig samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Rat Orm1 aa 1-200.
Alternative names
Alpha-1-acid glycoprotein, Orosomucoid, OMD, Orm1
Key facts
- Isotype
IgG2b
- Host species
Mouse
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 55.77% Glycerol (glycerin, glycerine), 44.12% PBS- Form
Liquid
- Clonality
Monoclonal
- Immunogen
- Recombinant Fragment Protein within Rat Orm1 aa 1-200. The exact immunogen used to generate this antibody is proprietary information. Database link P02764
- Clone number
C1
- Purification technique
Affinity purification Protein A/G
- Light chain type
kappa
- Concentration
- Purification notes
Purified from TCS.
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Alpha 1 Acid Glycoprotein also known as AGP or Alpha 1 Glycoprotein is a plasma protein with a molecular weight of approximately 41 to 43 kDa. This protein circulates primarily in the bloodstream and is produced mainly by the liver. AGP is known for its highly glycosylated structure carrying several branched oligosaccharide chains. It exhibits a significant capacity to bind various endogenous and exogenous lipophilic substances influencing their transport and distribution in the body.
- Biological function summary
AGP plays a role in modulating the immune response and maintaining homeostasis. As an acute-phase protein its levels rise significantly during inflammation infection and trauma where it acts to modulate the immune system. AGP does not exist as part of a larger protein complex but interacts with plasma lipoproteins and other glycoproteins aiding in its function of maintaining vascular integrity during acute-phase reactions.
- Pathways
Alpha 1 Glycoprotein serves as an important component in the inflammatory response and drug-binding pathways. In the inflammatory pathway AGP interacts with cytokines and acute-phase reactants adjusting the body’s inflammatory processes. It is also involved in the binding and distribution of drugs interacting with albumin and other transport proteins to influence the pharmacokinetics of many medications.
- Associated diseases and disorders
AGP levels change in response to conditions like rheumatoid arthritis and liver diseases. In rheumatoid arthritis its increased levels correlate with disease activity and inflammation. In liver diseases the production and plasma concentration of AGP can reflect hepatic synthesis capability. AGP's interaction with cytokines in these conditions often links it to elevated levels of other acute-phase proteins like C-reactive protein reflecting its participation in the pathophysiological processes of inflammation.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
8 product images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473), expandable thumbnail](https://content.abcam.com/products/images/alpha-1-acid-glycoprotein-agp-antibody-c1-ab239473--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img64837.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473)
Paraffin-embedded rat liver tissue stained for Alpha 1 Acid Glycoprotein/AGP using ab239473 at 30 μg/ml in immunohistochemical analysis. DAB staining.
![Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473), expandable thumbnail](https://content.abcam.com/products/images/alpha-1-acid-glycoprotein-agp-antibody-c1-ab239473--western-blot-img35973.jpg "Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473)")
Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473)
All lanes: Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473) at 2 µg/mL
All lanes: Recombinant rat Alpha 1 Acid Glycoprotein/AGP protein
SecondaryAll lanes: HRP Linked Rabbit Anti-Mouse IgG at 1/5000 dilution
Predicted band size: 24 kDa
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473), expandable thumbnail](https://content.abcam.com/products/images/alpha-1-acid-glycoprotein-agp-antibody-c1-ab239473--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img21862.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473)
Paraffin-embedded rat adrenal gland tissue stained for Alpha 1 Acid Glycoprotein/AGP using ab239473 at 30 μg/ml in immunohistochemical analysis. DAB staining.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473), expandable thumbnail](https://content.abcam.com/products/images/alpha-1-acid-glycoprotein-agp-antibody-c1-ab239473--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img114732.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473)
Paraffin-embedded rat stomach tissue stained for Alpha 1 Acid Glycoprotein/AGP using ab239473 at 30 μg/ml in immunohistochemical analysis. DAB staining.
![Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473), expandable thumbnail](https://content.abcam.com/products/images/alpha-1-acid-glycoprotein-agp-antibody-c1-ab239473--western-blot-img105057.jpg "Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473)")
Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473)
All lanes: Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473) at 2 µg/mL
Lane 1: Rat brain lysate
Lane 2: Rat cerebellum lysate
Lane 3: Pig brain lysate
SecondaryAll lanes: HRP Linked Rabbit Anti-Mouse IgG at 1/5000 dilution
Predicted band size: 24 kDa
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473), expandable thumbnail](https://content.abcam.com/products/images/alpha-1-acid-glycoprotein-agp-antibody-c1-ab239473--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img2304.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473)
Paraffin-embedded rat heart tissue stained for Alpha 1 Acid Glycoprotein/AGP using ab239473 at 30 μg/ml in immunohistochemical analysis. DAB staining.
![Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473), expandable thumbnail](https://content.abcam.com/products/images/alpha-1-acid-glycoprotein-agp-antibody-c1-ab239473--western-blot-img159177.jpg "Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473)")
Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473)
All lanes: Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473) at 2 µg/mL
All lanes: Rat liver lysate
Predicted band size: 24 kDa
![Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473), expandable thumbnail](https://content.abcam.com/products/images/alpha-1-acid-glycoprotein-agp-antibody-c1-ab239473--western-blot-img145551.jpg "Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473)")
Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473)
All lanes: Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473) at 2 µg/mL
All lanes: Rat testis lysate
Predicted band size: 24 kDa
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473), expandable thumbnail](https://content.abcam.com/products/images/alpha-1-acid-glycoprotein-agp-antibody-c1-ab239473--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img2304.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473)")
![Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473), expandable thumbnail](https://content.abcam.com/products/images/alpha-1-acid-glycoprotein-agp-antibody-c1-ab239473--western-blot-img159177.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473)")
![Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473), expandable thumbnail](https://content.abcam.com/products/images/alpha-1-acid-glycoprotein-agp-antibody-c1-ab239473--western-blot-img145551.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-Alpha 1 Acid Glycoprotein/AGP antibody [C1] (ab239473)")
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