AB231226

Anti-Alpha 2 Antiplasmin antibody

Name: Anti-Alpha 2 Antiplasmin antibody (ab231226) | Abcam
Brand: Abcam Limited
SKU: AB231226

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(2 Publications)

Rabbit Polyclonal Alpha 2 Antiplasmin antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat samples. Cited in 2 publications.

View Alternative Names

Pli, Serpinf2, Alpha-2-antiplasmin, Alpha-2-AP, Alpha-2-plasmin inhibitor, Serpin F2, Alpha-2-PI

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 2 Antiplasmin antibody (AB231226)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 2 Antiplasmin antibody (AB231226)

Formalin-fixed, paraffin-embedded rat liver tissue stained for Alpha 2 Antiplasmin using ab231226 at 2 μg/mL in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 2 Antiplasmin antibody (AB231226)

Formalin-fixed, paraffin-embedded rat adrenal tissue stained for Alpha 2 Antiplasmin using ab231226 at 2 μg/mL in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-Alpha 2 Antiplasmin antibody (AB231226)

All lanes:

Western blot - Anti-Alpha 2 Antiplasmin antibody (ab231226) at 2 µg/mL

All lanes:

Recombinant rat Alpha 2 Antiplasmin protein

Predicted band size: 55 kDa

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Supplier Data

Western blot - Anti-Alpha 2 Antiplasmin antibody (AB231226)

All lanes:

Western blot - Anti-Alpha 2 Antiplasmin antibody (ab231226) at 2 µg/mL

All lanes:

Mouse liver lysate

Predicted band size: 55 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat

Applications

IHC-P, WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Alpha 2 Antiplasmin also known as A2AP or anti-alpha 2 plays an important role in inhibiting the fibrinolytic system by inactivating plasmin. Weighing around 70 kDa this glycoprotein is mainly expressed in the liver and circulates in plasma. Its alternative names include alpha-2-antiplasmin and anti-alpha 2 which highlight its blocking role against excess plasmin action.

Biological function summary

Alpha 2 Antiplasmin functions as the primary inhibitor of plasmin blocking unwanted fibrinolysis. It can form a complex with fibrin which enhances its efficiency in preventing premature fibrin clot dissolution. This regulation of plasmin activity ensures the stability of clots essential for proper wound healing and controlling bleeding.

Pathways

Alpha 2 Antiplasmin engages significantly with the fibrinolysis and coagulation pathways. Its action balances the fibrinolytic process which involves transforming plasminogen to plasmin. Related proteins like plasminogen activator inhibitor also regulate plasmin maintaining equilibrium between clot formation and degradation.

Alpha 2 Antiplasmin has implications in hemorrhagic conditions and thrombotic disorders. Its deficiency might lead to excessive bleeding due to unregulated plasmin activity whilst elevated levels could contribute to thrombotic problems causing harmful clot formation. The interplay with plasminogen and its activation is important in understanding its disease linkages.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin (By similarity).

See full target information Serpinf2

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of orthopaedic translation 33:90-106 PubMed35330941

2022

3D printed porous sulfonated polyetheretherketone scaffold for cartilage repair: Potential and limitation.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiguo Yuan,Teng Long,Jue Zhang,Zhuocheng Lyu,Wei Zhang,Xiangchao Meng,Jin Qi,You Wang

Cell chemical biology 28:1728-1739.e5 PubMed34352225

2021

The role of SERPIN citrullination in thrombosis.

Applications

Unspecified application

Species

Unspecified reactive species

Ronak Tilvawala,Venkatesh V Nemmara,Archie C Reyes,Nicoletta Sorvillo,Ari J Salinger,Deya Cherpokova,Saeko Fukui,Sarah Gutch,Denisa Wagner,Paul R Thompson

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Alpha 2 Antiplasmin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 2 Antiplasmin antibody (AB231226)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha 2 Antiplasmin antibody (AB231226)

Western blot - Anti-Alpha 2 Antiplasmin antibody (AB231226)

Western blot - Anti-Alpha 2 Antiplasmin antibody (AB231226)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Alternative Products

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Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Product promise