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AB62770

Anti-Alpha 2 Antiplasmin antibody

5

(2 Reviews)

|

(3 Publications)

Rabbit Polyclonal Alpha 2 Antiplasmin antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Full Length Protein corresponding to Human SERPINF2.

View Alternative Names

AAP, PLI, SERPINF2, Alpha-2-antiplasmin, Alpha-2-AP, Alpha-2-plasmin inhibitor, Serpin F2, Alpha-2-PI

1 Images
Western blot - Anti-Alpha 2 Antiplasmin antibody (AB62770)
  • WB

Unknown

Western blot - Anti-Alpha 2 Antiplasmin antibody (AB62770)

All lanes:

Western blot - Anti-Alpha 2 Antiplasmin antibody (ab62770) at 1 µg/mL

All lanes:

Native human Alpha 2 Antiplasmin protein (<a href='/en-us/products/unavailable/native-human-alpha-2-antiplasmin-protein-ab77936'>ab77936</a>) at 0.01 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-preadsorbed-ab97080'>ab97080</a>) at 1/5000 dilution

Predicted band size: 55 kDa

true

Exposure time: 10s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Full Length Protein corresponding to Human SERPINF2. The exact immunogen used to generate this antibody is proprietary information.

P08697

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
>98% pure (SDS-PAGE).
Storage buffer
Constituents: 0.82% Sodium phosphate, 0.58% Sodium chloride, 0.0292% EDTA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Alpha 2 Antiplasmin also known as A2AP or anti-alpha 2 plays an important role in inhibiting the fibrinolytic system by inactivating plasmin. Weighing around 70 kDa this glycoprotein is mainly expressed in the liver and circulates in plasma. Its alternative names include alpha-2-antiplasmin and anti-alpha 2 which highlight its blocking role against excess plasmin action.
Biological function summary

Alpha 2 Antiplasmin functions as the primary inhibitor of plasmin blocking unwanted fibrinolysis. It can form a complex with fibrin which enhances its efficiency in preventing premature fibrin clot dissolution. This regulation of plasmin activity ensures the stability of clots essential for proper wound healing and controlling bleeding.

Pathways

Alpha 2 Antiplasmin engages significantly with the fibrinolysis and coagulation pathways. Its action balances the fibrinolytic process which involves transforming plasminogen to plasmin. Related proteins like plasminogen activator inhibitor also regulate plasmin maintaining equilibrium between clot formation and degradation.

Alpha 2 Antiplasmin has implications in hemorrhagic conditions and thrombotic disorders. Its deficiency might lead to excessive bleeding due to unregulated plasmin activity whilst elevated levels could contribute to thrombotic problems causing harmful clot formation. The interplay with plasminogen and its activation is important in understanding its disease linkages.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.
See full target information SERPINF2
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

NPJ Regenerative medicine 7:34 PubMed35773290

2022

Therapeutic use of α2-antiplasmin as an antifibrinolytic and hemostatic agent in surgery and regenerative medicine.

Applications

Unspecified application

Species

Unspecified reactive species

Jialu Liu,Ani Solanki,Michael J V White,Jeffrey A Hubbell,Priscilla S Briquez

Physiological reports 10:e15301 PubMed35531929

2022

Liver vitronectin release into the bloodstream increases due to reduced vagal muscarinic signaling after cerebral stroke in female mice.

Applications

Unspecified application

Species

Unspecified reactive species

Matthew P Keasey,Chiharu Lovins,Cuihong Jia,Theo Hagg

Journal of cellular and molecular medicine 16:865-76 PubMed21790972

2011

Activators and inhibitors of the plasminogen system in Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Rachel Barker,Patrick G Kehoe,Seth Love
View all publications
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Product promise

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