Anti-alpha 2C Adrenergic Receptor/ADRA2C antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The alpha 2C adrenergic receptor also known as ADRA2C alpha 2C receptor or simply 2C receptor is a G protein-coupled receptor (GPCR) that binds to catecholamines like norepinephrine and epinephrine. It exhibits a mass of approximately 50 kDa. This receptor forms a part of the adrenergic receptor family which plays a critical role in the sympathetic nervous system. ADRA2C is expressed in various tissues including the brain particularly in the neocortex hippocampus and amygdala as well as in blood vessels and the heart.

Biological function summary

The alpha 2C adrenergic receptor modulates neurotransmitter release and inhibits adenylate cyclase activity via its coupling with Gi/o proteins. It has an important role in synaptic transmission vasoconstriction and thermoregulation. In neurons it integrates into receptor complexes that include other adrenergic receptors offering a tightly regulated mechanism for maintaining homeostasis. The receptor contributes to feedback inhibition by controlling neurotransmitter levels in synapses which influences mood alertness and blood pressure.

Pathways

Alpha 2C adrenergic receptor contributes to the regulation of the signaling pathways involving cyclic adenosine monophosphate (cAMP) and calcium ion mobilization. It aligns with important pathways like the MAPK/ERK pathway which influences cellular processes such as proliferation and differentiation. Proteins such as beta adrenergic receptor kinase and G protein-coupled receptor kinases interact with ADRA2C affecting receptor desensitization and downregulation which are critical for accurate signaling events.

Associated diseases and disorders

Dysfunction in the alpha 2C adrenergic receptor associates with conditions like depression and hypertension. Abnormal receptor activity can lead to impaired norepinephrine regulation contributing to altered mood states and stress responses. In hypertension the receptor's role in vascular tone regulation becomes significant with interactions involving proteins like endothelial nitric oxide synthase impacting vasodilation and blood pressure. Understanding these connections provides insight into therapeutic strategies addressing symptoms linked to receptor anomalies.