Anti-alpha 2C Adrenergic Receptor/ADRA2C antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The alpha 2C adrenergic receptor modulates neurotransmitter release and inhibits adenylate cyclase activity via its coupling with Gi/o proteins. It has an important role in synaptic transmission vasoconstriction and thermoregulation. In neurons it integrates into receptor complexes that include other adrenergic receptors offering a tightly regulated mechanism for maintaining homeostasis. The receptor contributes to feedback inhibition by controlling neurotransmitter levels in synapses which influences mood alertness and blood pressure.

Pathways

Alpha 2C adrenergic receptor contributes to the regulation of the signaling pathways involving cyclic adenosine monophosphate (cAMP) and calcium ion mobilization. It aligns with important pathways like the MAPK/ERK pathway which influences cellular processes such as proliferation and differentiation. Proteins such as beta adrenergic receptor kinase and G protein-coupled receptor kinases interact with ADRA2C affecting receptor desensitization and downregulation which are critical for accurate signaling events.