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AB27160

Anti-alpha 2u-globulin antibody [1D11]

5

(2 Reviews)

|

(1 Publication)

Mouse Monoclonal alpha 2u-globulin antibody. Suitable for ELISA, WB, sELISA and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Rat Major urinary protein.

View Alternative Names

Major urinary protein, MUP, Allergen Rat n I, Alpha(2)-euglobulin, Alpha-2u-globulin, alpha-2u globulin PGCL1

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

1D11

Isotype

IgG2a

Light chain type

kappa

Carrier free

No

Reacts with

Rat

Applications

sELISA, WB, ELISA

applications

Immunogen

Native Full Length Protein corresponding to Rat Major urinary protein.

P02761

Specificity

ab27160 recognises alpha 2-microglobulin.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS, 2.9% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Alpha 2u-globulin also known as alpha-2-globulin or globulin alpha-2 is a protein primarily expressed in the liver of male rats. This protein belongs to the lipocalin family and typically ranges in molecular mass from 18 to 20 kDa. Alpha 2u-globulin can bind small hydrophobic molecules which plays an important role in its mechanical function as a transport protein in the blood plasma. It has a considerable concentration in male rat urine due to its high turnover rate.
Biological function summary

Alpha 2u-globulin functions as a carrier protein mediating the transfer of various substances like pheromones and other small ligands. It also serves in the protection and stabilization of these molecules. While it is not a part of a larger complex alpha 2u-globulin has a specific role in modulating olfactory sensitivity and impacting social and sexual signaling in rodents. The protein's ability to bind and transport molecules influences various physiological processes.

Pathways

The protein alpha 2u-globulin is involved in the transport and metabolism pathways of small molecules particularly those tied to lipid metabolism. It relates to other lipocalin family proteins that also partake in the transport of hydrophobic molecules such as apolipoprotein D. In these pathways the efficient binding and release of ligands by alpha 2u-globulin ensure a proper balance in pheromone signaling and lipid homeostasis.

Alpha 2u-globulin is connected to conditions like nephrotoxicity and hyaline droplet nephropathy. These conditions emerge due to the accumulation of this protein in kidney tissues often linked to exposure to specific chemical agents. In such cases alpha 2u-globulin interacts with other proteins involved in pathological responses including oxidative stress-related factors that influence nephropathic changes. Understanding these connections helps in assessing rodent models' relevance to human disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Major urinary proteins (Mups) bind and release pheromones. They may also protect pheromones from oxidation. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance. Acts as a kairomone, detected by the prey vomeronasal organ and inducing fear reactions in mice.
See full target information Major urinary protein
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Vaccine 14:359-68 PubMed8735545

1996

The effect of formaldehyde, hydrogen peroxide and genetic detoxification of pertussis toxin on epitope recognition by murine monoclonal antibodies.

Applications

Unspecified application

Species

Unspecified reactive species

P H Ibsen
View all publications
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