Anti-Alpha-crystallin hspX antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Alpha-crystallin hspX contributes to the stability and transparency of the eye lens by avoiding protein aggregation and maintaining lens crystallin clarity. In bacteria it forms part of a complex that assists in survival under hostile conditions such as heat shock or nutrient deprivation promoting bacterial persistence. This protein features small heat shock protein domains allowing it to interact with unstable proteins facilitating their refolding or marking them for degradation.

Pathways

Alpha-crystallin hspX engages in the stress response pathway protecting cells under various stress scenarios. In the eye lens it relates to the maintenance of lens transparency through the interaction with other crystallins. In bacterial cells it connects to the dormancy survival programs aiding in the organism's ability to withstand prolonged periods in hostile environments. Alpha-crystallin hspX often associates with other heat shock proteins enhancing the cell's ability to survive stress.