AB112972

Anti-alpha Lactalbumin antibody

Name: Anti-alpha Lactalbumin antibody (ab112972) | Abcam
Brand: Abcam Limited
SKU: AB112972
Price: 515 USD
Availability: InStock

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(2 Publications)

Goat Polyclonal alpha Lactalbumin antibody. Suitable for ICC, ELISA, WB, IHC-P and reacts with Cow samples. Cited in 2 publications.

View Alternative Names

ALACTA, LALBA, Alpha-lactalbumin, Lactose synthase B protein

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Cow

Applications

ICC, ELISA, WB, IHC-P

applications

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Reactivity data

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Antiserum was solid phase adsorbed to ensure specificity. ab112972 was isolated by affinity chromatography using antigen coupled to agarose beads.

Storage buffer

pH: 6.8 - 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Alpha-lactalbumin commonly known as lactalbumin or alpha-lactoglobulin has a mass of approximately 14.2 kDa. This protein is mainly expressed in the mammary glands of mammals where it serves an important function in lactose synthesis. It modifies the action of galactosyltransferase an enzyme to enable the transfer of sugar units resulting in the production of lactose. The biochemical role of this lactalbumin protein including its unique structure is important in adapting the lactation system to meet the nutritional needs of offspring.

Biological function summary

Alpha-lactalbumin's role is closely linked to the synthesis and secretion of milk. It functions as part of the lactose synthase complex which is essential for converting glucose to lactose. This conversion is important because lactose dictates milk osmotic pressure affecting milk volume and overall composition. In addition to its primary role in milk production this protein structure supports various cellular processes due to its ability to bind calcium and other ions.

Pathways

Alpha-lactalbumin participates mainly in the lactose synthesis pathway. In this metabolic map it interacts extensively with other proteins involved in milk production particularly beta-14-galactosyltransferase. This interaction enhances the efficiency of lactose production. Its presence in these pathways epitomizes the close relationship and cellular coordination needed for effective lactose synthesis during lactation.

Researchers have identified connections between alpha-lactalbumin and breast cancer as well as lactose intolerance. Changes in the expression levels of this protein can impact the development and regulation of tumors in breast tissue linked to interactions with proteins such as casein. Furthermore variants of alpha-lactalbumin can affect individuals with lactose intolerance where the protein's role in regulating lactose production must be managed to alleviate symptoms.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

See full target information LALBA

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Alimentary pharmacology & therapeutics 53:410-417 PubMed33264440

2020

Mucosal penetration and clearance of gluten and milk antigens in eosinophilic oesophagitis.

Applications

Unspecified application

Species

Unspecified reactive species

Anupama Ravi,Eric V Marietta,Jeffrey A Alexander,Kathryn Peterson,Crystal Lavey,Debra M Geno,Joseph A Murray,David A Katzka

The Journal of reproduction and development 61:145-53 PubMed25740096

2015

Collagen complexes increase the efficiency of iPS cells generated using fibroblasts from adult mice.

Applications

Unspecified application

Species

Unspecified reactive species

Byung-Soo Chang,Yun-Jung Choi,Jin-Hoi Kim

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-alpha Lactalbumin antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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