AB178431

Anti-alpha Lactalbumin antibody [EPR12460]

RabMAb
Recombinant
What is this?

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(2 Publications)

Rabbit Recombinant Monoclonal alpha Lactalbumin antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

View Alternative Names

LYZL7, LALBA, Alpha-lactalbumin, Lactose synthase B protein, Lysozyme-like protein 7

1 Images

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Western blot - Anti-alpha Lactalbumin antibody [EPR12460] (AB178431)

All lanes:

Western blot - Anti-alpha Lactalbumin antibody [EPR12460] (ab178431) at 1/1000 dilution

All lanes:

Human milk lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP conjugated antibody

Predicted band size: 16 kDa

true

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR12460

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Alpha-lactalbumin commonly known as lactalbumin or alpha-lactoglobulin has a mass of approximately 14.2 kDa. This protein is mainly expressed in the mammary glands of mammals where it serves an important function in lactose synthesis. It modifies the action of galactosyltransferase an enzyme to enable the transfer of sugar units resulting in the production of lactose. The biochemical role of this lactalbumin protein including its unique structure is important in adapting the lactation system to meet the nutritional needs of offspring.

Biological function summary

Alpha-lactalbumin's role is closely linked to the synthesis and secretion of milk. It functions as part of the lactose synthase complex which is essential for converting glucose to lactose. This conversion is important because lactose dictates milk osmotic pressure affecting milk volume and overall composition. In addition to its primary role in milk production this protein structure supports various cellular processes due to its ability to bind calcium and other ions.

Pathways

Alpha-lactalbumin participates mainly in the lactose synthesis pathway. In this metabolic map it interacts extensively with other proteins involved in milk production particularly beta-14-galactosyltransferase. This interaction enhances the efficiency of lactose production. Its presence in these pathways epitomizes the close relationship and cellular coordination needed for effective lactose synthesis during lactation.

Researchers have identified connections between alpha-lactalbumin and breast cancer as well as lactose intolerance. Changes in the expression levels of this protein can impact the development and regulation of tumors in breast tissue linked to interactions with proteins such as casein. Furthermore variants of alpha-lactalbumin can affect individuals with lactose intolerance where the protein's role in regulating lactose production must be managed to alleviate symptoms.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

See full target information LALBA

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of extracellular vesicles 13:e12422 PubMed38602306

2024

Neonatal enteroids absorb extracellular vesicles from human milk-fed infant digestive fluid.

Applications

Unspecified application

Species

Unspecified reactive species

Claire Yung,Yang Zhang,Madeline Kuhn,Randall J Armstrong,Amy Olyaei,Molly Aloia,Brian Scottoline,Sarah F Andres

Nature communications 13:4291 PubMed35879296

2022

Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ.

Applications

Unspecified application

Species

Unspecified reactive species

Qian Zhou,Wan-Wan Sun,Jia-Cong Chen,Hui-Lu Zhang,Jie Liu,Yan Lin,Peng-Cheng Lin,Bai-Xing Wu,Yan-Peng An,Lin Huang,Wen-Xing Sun,Xin-Wen Zhou,Yi-Ming Li,Yi-Yuan Yuan,Jian-Yuan Zhao,Wei Xu,Shi-Min Zhao

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-alpha Lactalbumin antibody [EPR12460]

Western blot - Anti-alpha Lactalbumin antibody [EPR12460] (AB178431)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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