AB231028

Anti-Angiogenin antibody

Name: Anti-Angiogenin antibody (ab231028) | Abcam
Brand: Abcam Limited
SKU: AB231028

Be the first to review this product! Submit a review

(1 Publication)

Rabbit Polyclonal Angiogenin antibody. Suitable for WB, IHC-P and reacts with Rat samples. Cited in 1 publication.

View Alternative Names

Ang

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Angiogenin antibody (AB231028)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Angiogenin antibody (AB231028)

Formalin-fixed, paraffin-embedded rat brain tissue stained for Angiogenin with ab231028 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-Angiogenin antibody (AB231028)

All lanes:

Western blot - Anti-Angiogenin antibody (ab231028) at 2 µg/mL

All lanes:

Rat serum

Predicted band size: 17 kDa

false

Supplier Data

Western blot - Anti-Angiogenin antibody (AB231028)

All lanes:

Western blot - Anti-Angiogenin antibody (ab231028) at 2 µg/mL

All lanes:

Rat liver lysate

Predicted band size: 17 kDa

false

Supplier Data

Western blot - Anti-Angiogenin antibody (AB231028)

All lanes:

Western blot - Anti-Angiogenin antibody (ab231028) at 2 µg/mL

All lanes:

Recombinant rat Angiogenin protein

Predicted band size: 17 kDa

false

Supplier Data

Western blot - Anti-Angiogenin antibody (AB231028)

All lanes:

Western blot - Anti-Angiogenin antibody (ab231028) at 2 µg/mL

All lanes:

Rat heart lysate

Predicted band size: 17 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

IHC-P, WB

applications

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 mg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

ab231028 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Angiogenin also known as ANG is a small protein with a molecular mass of approximately 14 kDa. It belongs to the ribonuclease A superfamily. Angiogenin expression occurs in a variety of tissues with notably pronounced levels in the liver pancreas and placenta indicating its widespread biological importance. In addition to its primary name it appears in the context of research under alternative names like KIT ANG and elisa ang reflecting its use and identification in various experimental assays.

Biological function summary

Angiogenin significantly contributes to the process of angiogenesis the formation of new blood vessels from pre-existing vascular structures. It characterizes acts as both a ribonuclease and a potent angiogenic factor. Although not part of a multi-protein complex angiogenin interacts with endothelial cells to promote their growth and migration. Angiogenin facilitates these cellular behaviors by triggering pathways that enhance cell survival and proliferation essential for healthy tissue development and repair.

Pathways

Angiogenin is intricately involved in the angiogenesis pathway a critical process for both physiological and pathological conditions. It interacts with proteins such as VEGF (vascular endothelial growth factor) which plays an essential role in vascular function. Angiogenin's interaction with these pathways enhances cellular responses to external stimuli maintaining vascular integrity and supporting tissue regeneration under stress or injury conditions.

Angiogenin has connections to conditions like cancer and amyotrophic lateral sclerosis (ALS). Aberrant regulation of angiogenin can contribute to tumorigenesis by promoting excessive angiogenesis aiding the growth and spread of cancerous cells. In ALS altered angiogenin function associates with neurodegenerative processes linking its function to proteins such as superoxide dismutase 1 (SOD1). Understanding angiogenin's role in these diseases aids in uncovering therapeutic targets and developing treatment strategies.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

See full target information Angiogenin

style

left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 135: PubMed40166934

2025

Lysyl hydroxylase 2 glucosylates collagen VI to drive lung cancer progression.

Applications

Unspecified application

Species

Unspecified reactive species

Shike Wang,Houfu Guo,Reo Fukushima,Masahiko Terajima,Min Liu,Guan-Yu Xiao,Lenka Koudelková,Chao Wu,Xin Liu,Jiang Yu,Emma Burris,Jun Xu,Alvise Schiavinato,William K Russell,Mitsuo Yamauchi,Xiaochao Tan,Jonathan M Kurie

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Angiogenin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Angiogenin antibody (AB231028)

Western blot - Anti-Angiogenin antibody (AB231028)

Western blot - Anti-Angiogenin antibody (AB231028)

Western blot - Anti-Angiogenin antibody (AB231028)

Western blot - Anti-Angiogenin antibody (AB231028)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Alternative Products

Primary Antibodies

Primary Antibodies

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Product promise