AB171976

Anti-Angiomotin like 1 antibody [EPR11803-97]

RabMAb
Recombinant
What is this?

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(2 Publications)

Rabbit Recombinant Monoclonal Angiomotin like 1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

View Alternative Names

Angiomotin-like protein 1, AMOTL1

1 Images

Supplier Data

Western blot - Anti-Angiomotin like 1 antibody [EPR11803-97] (AB171976)

All lanes:

Western blot - Anti-Angiomotin like 1 antibody [EPR11803-97] (ab171976) at 1/1000 dilution

Lane 1:

HeLa cell lysate at 10 µg

Lane 2:

SH-SY5Y cell lysate at 10 µg

Predicted band size: 107 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR11803-97

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Angiomotin like 1 (AMOTL1) also known as Angiomotin-like protein 1 is a member of the angiomotin family known for its role in angiogenesis. This protein has a molecular mass of approximately 90 kDa and is expressed in various tissues including endothelial cells. AMOTL1 interacts with other proteins to influence cell shape and migration by maintaining the integrity of tight junctions and actin cytoskeleton organization.

Biological function summary

Angiomotin-like protein 1 plays a role in regulating cell proliferation and migration. AMOTL1 associates with the angiomotin protein complex which includes angiomotin and angiomotin like 2 (AMOTL2). The protein has functions in signaling pathways that are important for tissue architecture and cellular polarity. AMOTL1 facilitates the localization and stabilization of other cell signaling proteins to coordinate these complex biological processes effectively.

Pathways

Angiomotin like protein 1 is involved in the Hippo signaling pathway a critical regulator of cell growth and apoptosis. In this pathway AMOTL1 interacts with proteins such as YAP/TAZ acting as a spatial regulator that limits their activity within the nucleus. Another important pathway involving AMOTL1 is the tight junction pathway where it helps maintain cell-cell adhesion and tissue integrity by interacting with ZO-1 and other structural proteins.

Angiomotin-like protein 1 has been linked to cancer progression particularly in breast and liver cancers. AMOTL1 influences tumor cell migration and invasion by modulating the localization of YAP/TAZ proteins. Additionally studies have shown a relation to vascular diseases as AMOTL1 affects endothelial cell function and angiogenesis potentially connecting it to disorders like atherosclerosis. Understanding these relationships may aid in developing targeted therapies for these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.

See full target information Angiomotin-like protein 1

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Biomolecules 9: PubMed31627466

2019

YAP Inhibition by Nuciferine via AMPK-Mediated Downregulation of HMGCR Sensitizes Pancreatic Cancer Cells to Gemcitabine.

Applications

Unspecified application

Species

Unspecified reactive species

Ling Zhou,Qiaoyun Wang,Han Zhang,Youjie Li,Shuyang Xie,Maolei Xu

Nature communications 9:1739 PubMed29712898

2018

C/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation.

Applications

Unspecified application

Species

Unspecified reactive species

Dan Liu,Xiao-Xue Zhang,Meng-Chen Li,Can-Hui Cao,Dong-Yi Wan,Bi-Xin Xi,Jia-Hong Tan,Ji Wang,Zong-Yuan Yang,Xin-Xia Feng,Fei Ye,Gang Chen,Peng Wu,Ling Xi,Hui Wang,Jian-Feng Zhou,Zuo-Hua Feng,Ding Ma,Qing-Lei Gao

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Angiomotin like 1 antibody [EPR11803-97]

Western blot - Anti-Angiomotin like 1 antibody [EPR11803-97] (AB171976)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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Product promise