Rabbit Polyclonal Angiopoietin-like 4/ANGPTL4 antibody. Suitable for WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human ANGPTL4.
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- Aging 16:8348-83602023ANGPTL4, a direct target of hsa-miR-133a-3p, accelerates lung adenocarcinoma lipid metabolism, proliferation and invasion.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQihao Hu,Shi Chen,Yukun Li,Teng Hu,Jianpeng Hu,Cheng Wang,Fei Yang,Xiang Yang,Feng Zhou,Zhengdong Liu,Wei Xu,Ji ZhangPubMed 38159259
- The Journal of experimental medicine 220:2022Primary tumor-derived systemic nANGPTL4 inhibits metastasis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCorinne Hübers,Ashik Ahmed Abdul Pari,Denise Grieshober,Martin Petkov,Alexander Schmidt,Tatjana Messmer,Christian Moritz Heyer,Sebastian Schölch,Stephanie S Kapel,Nicolas Gengenbacher,Mahak Singhal,Benjamin Schieb,Claudine Fricke,Rainer Will,Kim Remans,Jochen Sven Utikal,Christoph Reissfelder,Matthias Schlesner,Kairbaan M Hodivala-Dilke,Sander Kersten,Sergij Goerdt,Hellmut G Augustin,Moritz FelchtPubMed 36269299
- BMC cancer 20:8782020ANGPTL4 overexpression inhibits tumor cell adhesion and migration and predicts favorable prognosis of triple-negative breast cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYu-Chen Cai et. al.PubMed 32928141
- Frontiers in immunology 10:9502019Reduced Angiopoietin-Like 4 Expression in Multiple Sclerosis Lesions Facilitates Lipid Uptake by Phagocytes via Modulation of Lipoprotein-Lipase Activity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlwin Kamermans et. al.PubMed 31130950
- Scientific reports 8:119542018Enzyme-modified non-oxidized LDL (ELDL) induces human coronary artery smooth muscle cell transformation to a migratory and osteoblast-like phenotype.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBijoy Chellan et. al.PubMed 30097618
- Oncotarget 8:54966-549772017TGF-β2-induced ANGPTL4 expression promotes tumor progression and osteoclast differentiation in giant cell tumor of bone.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBo Li,Ming Qian,Hao Cao,Qi Jia,Zhipeng Wu,Xinghai Yang,Tianyi Ma,Haifeng Wei,Tianrui Chen,Jianru XiaoPubMed 28903395
- PloS one 8:e731462013c-Myc is essential to prevent endothelial pro-inflammatory senescent phenotype.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human ANGPTL4. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BY76
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Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.1-0.5 µg/mL | Notes The detection limit for Angiopoietin-like 4/ANGPTL4 is approximately 2.5ng/lane under non-reducing and reducing conditions. |
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Target data
Function
Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:19270337, PubMed:21398697, PubMed:27929370, PubMed:29899144). May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (PubMed:14583458, PubMed:17068295). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (PubMed:17068295). Depending on context, may modulate tumor-related angiogenesis (By similarity). ANGPTL4 N-terminal chain. Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:19270337, PubMed:21398697, PubMed:27929370, PubMed:29899144). Has higher activity in LPL inactivation than the uncleaved protein (PubMed:19270337, PubMed:21398697).
Alternative names
ARP4, HFARP, PGAR, PP1158, PSEC0166, UNQ171/PRO197, ANGPTL4, Angiopoietin-related protein 4, Angiopoietin-like protein 4, Hepatic fibrinogen/angiopoietin-related protein
Recommended products
Rabbit Polyclonal Angiopoietin-like 4/ANGPTL4 antibody. Suitable for WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human ANGPTL4.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human ANGPTL4. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BY76
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Angiopoietin-like 4 also known as ANGPTL4 like4 or ANGPTL4 protein is a glycoprotein with an approximate mass of 50 kDa. It plays a role in lipid metabolism by inhibiting lipoprotein lipase which reduces the breakdown of triglycerides. ANGPTL4 protein is secreted by liver adipose tissue and placenta showing expression in response to fasting and during low insulin states. This expression pattern connects its function to energy homeostasis and metabolic regulation.
- Biological function summary
ANGPTL4 protein influences processes such as lipid metabolism angiogenesis and wound healing. It does not integrate into a large protein complex but functions independently to exert its effects. Inhibition of lipoprotein lipase by ANGPTL4 decreases adipose tissue fat storage and modulates plasma lipid levels. This modulation plays a critical role in maintaining energy balance and glucose homeostasis particularly under metabolic stress conditions.
- Pathways
The functionality of ANGPTL4 protein intersects with the PPAR (Peroxisome Proliferator-Activated Receptor) signaling pathway and the glucose homeostasis pathway. It interacts with other proteins such as PPAR-alpha and PPAR-gamma which regulate genes involved in fatty acid oxidation and lipid transport. This interaction influences the body's response to fasting and caloric restriction by altering lipid metabolism and ensuring efficient energy use.
- Associated diseases and disorders
ANGPTL4 protein correlates with cardiovascular diseases and cancer. Elevated levels of ANGPTL4 associate with an increased risk for atherosclerosis due to its role in lipid metabolism disturbance. In cancer particularly gastric cancer ANGPTL4 influences tumor metastasis by promoting angiogenesis. Its effects on these diseases link to proteins like VEGF in angiogenesis and other metabolic regulators in cardiovascular conditions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-Angiopoietin-like 4/ANGPTL4 antibody (ab115798)
All lanes: Western blot - Anti-Angiopoietin-like 4/ANGPTL4 antibody (ab115798)
Lane 1: Human Placenta Tissue Lysate at 50 µg
Lane 2: SMMC Whole Cell Lysate at 40 µg
Lane 3: HeLa Whole Cell Lysate at 40 µg
Predicted band size: 45 kDa
Western blot - Anti-Angiopoietin-like 4/ANGPTL4 antibody (ab115798)
All lanes: Western blot - Anti-Angiopoietin-like 4/ANGPTL4 antibody (ab115798)
Lane 1: Smmc Whole Cell Lysate
Lane 2: A549 Whole Cell Lysate
Lane 3: U87 Whole Cell Lysate
Lane 4: 293T Whole Cell Lysate
Lane 5: SGC Whole Cell Lysate
Predicted band size: 45 kDa
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