Rabbit Polyclonal Angiotensin Converting Enzyme 1 antibody. Suitable for WB and reacts with Recombinant fragment samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human ACE.
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- Cytotechnology 73:745-7542021Pulmonary AngII promotes LPS-induced lung inflammation by regulating microRNA-143.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShenglan Wang,Yan Tan,Tingting Yang,Chen Liu,Rufang LiPubMed 34493899
- Frontiers in physiology 12:6422742021Diuretic Action of Apelin-13 Mediated by Inhibiting cAMP/PKA/sPRR Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYanting Chen,Chuanming Xu,Jiajia Hu,Mokan Deng,Qixiang Qiu,Shiqi Mo,Yanhua Du,Tianxin YangPubMed 33868005
- BMC physiology 15:22015Antenatal maternal low protein diet: ACE-2 in the mouse lung and sexually dimorphic programming of hypertension.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRavi Goyal et. al.PubMed 25971747
- American journal of physiology. Cell physiology 307:C1093-1012014Induction of angiotensin-converting enzyme after miR-143/145 deletion is critical for impaired smooth muscle contractility.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDiana Dahan et. al.PubMed 25273883
- Journal of the renin-angiotensin-aldosterone system : JRAAS 14:137-452012Antenatal maternal protein deprivation: sexually dimorphic programming of the pancreatic renin-angiotensin system.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRavi Goyal,Christine Wong,Jonathan Van Wickle,Lawrence D LongoPubMed 22898440
- Placenta 32:134-92010Antenatal maternal hypoxic stress: adaptations of the placental renin-angiotensin system in the mouse.Applications:Unspecified applicationReactive species:Unspecified reactive speciesR Goyal,R Lister,A Leitzke,D Goyal,C P Gheorghe,L D LongoPubMed 21130492
- Reproductive sciences (Thousand Oaks, Calif.) 18:180-92010Antenatal maternal hypoxic stress: adaptations in fetal lung Renin-Angiotensin system.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRavi Goyal,Arthur Leitzke,Dipali Goyal,Ciprian P Gheorghe,Lawrence D LongoPubMed 20978179
- The Journal of clinical investigation 119:2634-472009Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster.Applications:WBReactive species:MouseThomas Boettger,Nadine Beetz,Sawa Kostin,Johanna Schneider,Marcus Krüger,Lutz Hein,Thomas BraunPubMed 19690389
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Synthetic Peptide within Human ACE. The exact immunogen used to generate this antibody is proprietary information. Database link P12821
Reactivity data
Select an application| WB | |
|---|---|
| Rat | Predicted |
| Recombinant fragment | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant fragment | Dilution info - | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
Associated Products
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Target data
Function
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Alternative names
Angiotensin-converting enzyme, ACE, Dipeptidyl carboxypeptidase I, Kininase II, DCP1, DCP, ACE
Recommended products
Rabbit Polyclonal Angiotensin Converting Enzyme 1 antibody. Suitable for WB and reacts with Recombinant fragment samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human ACE.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Synthetic Peptide within Human ACE. The exact immunogen used to generate this antibody is proprietary information. Database link P12821
- Purification technique
Affinity purification Immunogen
- Specificity
This antibody is specific for Angiotensin Converting Enzyme 1.
- Concentration
- Purification notes
This antibody has been peptide-affinity purified.
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Angiotensin Converting Enzyme 1 also known as ACE1 or ACE is an important enzyme in the renin-angiotensin system. This enzyme exhibits a significant role in blood pressure regulation. ACE1 is a zinc-metallopeptidase with a molecular weight of approximately 130 kDa. It converts angiotensin I into the potent vasoconstrictor angiotensin II a critical function in cardiovascular physiology. ACE1 is widely expressed in endothelial cells particularly in the lungs kidneys and the small intestine.
- Biological function summary
The enzyme generates angiotensin II by cleaving angiotensin I. Angiotensin II an important effector peptide impacts cardiovascular and renal systems influencing vasoconstriction and fluid balance. While not directly forming a complex ACE1's activity increases the potency of angiotensin II which binds to angiotensin II receptors to exert its effects therefore indirectly forming a functional signaling complex.
- Pathways
ACE1 plays a central role in the renin-angiotensin system and the kallikrein-kinin system. The enzyme's activity boosts angiotensin II production which connects it to the regulation of blood pressure via the renin-angiotensin pathway. ACE1 also indirectly interacts with proteins like bradykinin by degrading them modulating kinin-related functions and influencing inflammation and tension in vascular smooth muscle.
- Associated diseases and disorders
Understanding ACE1 is important for addressing hypertension and congestive heart failure. ACE1's conversion of angiotensin I to angiotensin II means overactivity can cause elevated blood pressure leading to hypertension. This makes ACE inhibitors such as lisinopril and ramipril therapeutic for these conditions. Furthermore its connection with aldosterone production places ACE1 in relevance to heart failure as excessive aldosterone can cause detrimental remodeling of cardiac tissue.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-Angiotensin Converting Enzyme 1 antibody (ab39172)
All lanes: Western blot - Anti-Angiotensin Converting Enzyme 1 antibody (ab39172) at 1/1000 dilution
Lane 1: ACE1 at 0.05 µg
Lane 2: ACE1 at 0.01 µg
Lane 3: ACE1 at 0.001 µg
Predicted band size: 150 kDa
Observed band size: 170 kDa
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