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AB53951

Anti-Angiotensin I antibody

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(1 Publication)

Rabbit Polyclonal Angiotensinogen antibody. Suitable for IP, ELISA, RIA and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human AGT aa 1-50 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

SERPINA8, AGT, Angiotensinogen, Serpin A8

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ELISA, IP, RIA

applications

Immunogen

Synthetic Peptide within Human AGT aa 1-50 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P01019

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Alternative Products

Primary Antibodies

AB81270

Anti-Angiotensinogen antibody [EPR3136Y]

RabMAb|Recombinant

Western blot - Anti-Angiotensinogen antibody [EPR3136Y] (AB81270)

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Primary Antibodies

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Primary Antibodies

AB124737

Anti-Kininogen 1 antibody [EPR6097]

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Primary Antibodies

AB32503

Anti-Bax antibody [E63]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bax antibody [E63] (AB32503)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "RIA" : {"fullname" : "Radioimmunoassay", "shortname":"RIA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "RIA-species-checked": "guaranteed", "RIA-species-dilution-info": "", "RIA-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "RIA-species-checked": "predicted", "RIA-species-dilution-info": "", "RIA-species-notes": "" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "RIA-species-checked": "predicted", "RIA-species-dilution-info": "", "RIA-species-notes": "" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "RIA-species-checked": "predicted", "RIA-species-dilution-info": "", "RIA-species-notes": "" }, "Dog": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "RIA-species-checked": "predicted", "RIA-species-dilution-info": "", "RIA-species-notes": "" }, "Horse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "RIA-species-checked": "predicted", "RIA-species-dilution-info": "", "RIA-species-notes": "" }, "Sheep": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "RIA-species-checked": "predicted", "RIA-species-dilution-info": "", "RIA-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Angiotensin I also known as Ang I acts as a precursor in the renin-angiotensin system. Its molecular mass is approximately 1296.5 Da. Angiotensin I originates from the cleavage of angiotensinogen by the enzyme renin primarily in the liver. This decapeptide circulates in the bloodstream and serves as a substrate for further enzymatic reactions. Although it itself does not have known biological activity its conversion to angiotensin II enhances its significance.
Biological function summary

The conversion of angiotensin I into angiotensin II is an important step. This reaction occurs in the lungs facilitated by the angiotensin-converting enzyme (ACE). Angiotensin II has much greater activity and plays an important role in increasing blood pressure and regulating blood volume. Angiotensin I serves as an important precursor member but not an active component of this system and enemies an intricate balance with other components like prorenin and renin.

Pathways

Angiotensin I's role is central in the renin-angiotensin-aldosterone system (RAAS). This pathway involves the conversion sequence involving renin Ang I ACE and angiotensin II leading further to the release of aldosterone. Angiotensin I plays a continuous part alongside other proteins such as ACE and angiotensinogen that integrate into the larger RAAS highlighting its intermediary function within this cardiovascular regulatory system.

Angiotensin I indirectly connects to hypertension and heart failure through its conversion to angiotensin II. Elevated levels of angiotensin II the main active agent can contribute to increased blood pressure and cardiovascular strain. The connection between angiotensin I and ACE accentuates its role in this pathological process even though Ang I itself is not directly pathogenic. Understanding this relationship provides insights into hypertension treatment strategies focusing on targeting ACE or using angiotensin I ELISA kits to monitor systemic levels.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.. Angiotensin-2. Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone (PubMed : 10619573, PubMed : 17138938). Acts by binding to angiotensin receptors AGTR1 and AGTR2 (PubMed : 1567413). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).. Angiotensin-3. Stimulates aldosterone release.. Angiotensin 1-7. Is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (By similarity).
See full target information AGT
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 17:2837-2844 PubMed29257268

2017

Activation of the LKB1‑SIK1 signaling pathway inhibits the TGF‑β‑mediated epithelial‑mesenchymal transition and apoptosis resistance of ovarian carcinoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Hong,Jianmei Zhang,Wenlan Yang
View all publications
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