AB286174

Anti-Angiotensin II antibody

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(1 Publication)

Rabbit Polyclonal Angiotensinogen antibody. Suitable for WB and reacts with Synthetic peptide - Human samples. Cited in 1 publication.

View Alternative Names

SERPINA8, AGT, Angiotensinogen, Serpin A8

1 Images

Supplier Data

Western blot - Anti-Angiotensin II antibody (AB286174)

All lanes:

Western blot - Anti-Angiotensin II antibody (ab286174)

All lanes:

Angiotensin II peptide conjugated to BSA 1-4 µg

Predicted band size: 53 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called A1588 Anti-Angiotensin II Antibody. A1588-100 is the same size as the 100 µg size of ab286174.

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Properties and storage information

Form

Liquid

Purification notes

Affinity purified rabbit IgG

Storage buffer

pH: 7.2 Preservative: 0.03% Proclin 300 Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA, 0.15% EDTA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Angiotensin II also known as Ang II is a potent peptide hormone involved in various physiological activities. It has a mass of approximately 1 kDa. Angiotensin II is formed from angiotensin I through the action of the enzyme angiotensin-converting enzyme (ACE). This peptide primarily expresses in the blood vessels adrenal gland and kidney. It binds mainly to angiotensin II receptor type 1 (AT1 receptor) and type 2 (AT2 receptor) to mediate its effects.

Biological function summary

This peptide hormone regulates blood pressure and fluid balance. It acts as part of the renin-angiotensin system (RAS) and triggers vasoconstriction which increases blood pressure. By stimulating the release of aldosterone it facilitates sodium and water retention further affecting blood volume. The regulation of these mechanisms does not occur in isolation; Angiotensin II integrates with other signaling molecules like reactive oxygen species to exert its functions.

Pathways

The renin-angiotensin system is the primary pathway where Angiotensin II plays an important role. It connects closely with the endothelial and inflammatory pathways influencing cardiovascular health. It interacts with various proteins in these pathways including ACE and the AT1 and AT2 receptors which are critical for its effects on vascular tone and cellular proliferation. Additionally through the RAS Angiotensin II cross-talks with the kinin-kallikrein system which balances vasoconstrictive and vasodilatory actions.

Angiotensin II is linked to hypertension and heart failure. Elevated levels can contribute to increased blood pressure promoting vascular and cardiac remodeling through interactions with aldosterone and endothelin-1. In heart failure Angiotensin II exacerbates the progression of the disease by promoting fibrosis and hypertrophy via the AT1 receptor. The modulation of Angiotensin II activity through ACE inhibitors or receptor blockers is therapeutic in treating these conditions highlighting the peptide's critical role in these pathological states.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.. Angiotensin-2. Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone (PubMed : 10619573, PubMed : 17138938). Acts by binding to angiotensin receptors AGTR1 and AGTR2 (PubMed : 1567413). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).. Angiotensin-3. Stimulates aldosterone release.. Angiotensin 1-7. Is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (By similarity).

See full target information AGT

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Drug development research 84:1008-1017 PubMed37114746

2023

All-trans retinoic acid inhibits oxidative stress via ACE2/Ang (1-7)/MasR pathway in renal tubular epithelial cells stimulated with high glucose.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaojuan Zhu,Zhixiang Mou,Wei Han,Lan Chen

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Angiotensin II antibody

Western blot - Anti-Angiotensin II antibody (AB286174)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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