Anti-Angiotensin II Type 2 Receptor antibody [EPR3876]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The Angiotensin II Type 2 Receptor also known as the AT2 receptor mechanically functions by binding to angiotensin II a peptide hormone that regulates blood pressure. The AT2 receptor has a mass of approximately 41 kDa. It is mainly expressed in fetal tissues as well as in adult tissues like heart kidney adrenal gland and brain. This receptor belongs to the G protein-coupled receptor family and plays a counter-regulatory role compared to the Angiotensin II Type 1 Receptor (AT1 receptor).

Biological function summary

AT2 receptor mediates actions opposite to those of the AT1 receptor by promoting vasodilation natriuresis and inhibition of cell growth. It does not form stable complexes with the AT1 receptor but acts independently. Additionally the AT2 receptor participates in neural differentiation and can induce apoptosis in specific cell types. These activities highlight its regulatory role in cardiovascular and renal systems.

Pathways

The AT2 receptor is an important player in the renin-angiotensin system (RAS) which is critical for maintaining cardiovascular homeostasis. It antagonizes the effects of the AT1 receptor within the RAS pathway counteracting vasoconstriction and cell proliferation. The AT2 receptor also intersects with the bradykinin pathway further influencing vascular tone and growth inhibition. These interactions illustrate the receptor’s comprehensive role in balancing blood pressure and cellular responses.

Associated diseases and disorders

AT2 receptor involvement has been noted in cardiovascular disease including hypertension and heart failure. It ameliorates conditions induced by excessive AT1 receptor activation by promoting vasodilation and anti-inflammatory effects. Additionally research connects the AT2 receptor to renal disorders such as diabetic nephropathy where it counters profibrotic and hypertensive mechanisms instigated by the AT1 receptor. Therefore understanding its disease-related mechanisms can inform therapeutic strategies for these conditions.