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AB199179

Anti-ANGPTL7 antibody

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(1 Publication)

Rabbit Polyclonal ANGPTL7 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ANGPTL7.

View Alternative Names

CDT6, UNQ313/PRO356, ANGPTL7, Angiopoietin-related protein 7, Angiopoietin-like factor, Angiopoietin-like protein 7, Cornea-derived transcript 6 protein

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ANGPTL7. The exact immunogen used to generate this antibody is proprietary information.

O43827

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Complementary Products

Assay Kits

AB313507

Human ANGPTL7 ELISA Kit

Sandwich ELISA - Human ANGPTL7 ELISA Kit (AB313507)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Assay Kits

AB313507

Human ANGPTL7 ELISA Kit

Sandwich ELISA - Human ANGPTL7 ELISA Kit (AB313507)

  • 0
  • 0
Primary Antibodies

AB17857

Anti-Mitochondria antibody [SPM198], prediluted

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mitochondria antibody [SPM198], prediluted (AB17857)

  • 0
  • 0
Primary Antibodies

AB217791

Anti-CHMP4B + CHMP4C antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHMP4B + CHMP4C antibody (AB217791)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ANGPTL7 protein also known as Angiopoietin-like 7 plays a role in mechanistic processes. It has a molecular mass of about 45 kDa. ANGPTL7 is expressed primarily in the cornea and trabecular meshwork of the eye but it is also found in other tissues like the liver and heart. This protein is part of the larger angiopoietin-like protein family which is involved in numerous functions related to angiogenesis and metabolism.
Biological function summary

ANGPTL7 participates in the regulation of extracellular matrix composition and collagen deposition affecting tissue remodeling. It does not form a known complex with other molecules but influences the structural integrity of tissues through its regulatory actions. ANGPTL7 potentially interacts with cellular receptors to mediate these effects contributing to maintenance and repair of tissue structures.

Pathways

ANGPTL7 interacts within the framework of the TGF-beta signaling pathway influencing cellular growth and differentiation. Another important pathway involving ANGPTL7 is the Wnt signaling cascade which is important for various developmental processes. In these pathways ANGPTL7 has functional interactions with proteins such as TGF-beta and beta-catenin modulating their activity and impact on cellular functions.

ANGPTL7 has connections to ocular diseases like glaucoma where its expression levels alter the outflow facility of aqueous humor. It also relates to fibrosis since the regulation of collagen deposition is an important factor. The involvement of ANGPTL7 in these conditions links it with proteins such as myocilin in glaucoma and TIMP-1 in fibrosis highlighting its role in pathological tissue remodeling.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure (PubMed : 21199193). Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency (PubMed : 25622036).
See full target information ANGPTL7
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 15:e0240129 PubMed33048975

2020

Gap junction protein beta 4 plays an important role in cardiac function in humans, rodents, and zebrafish.

Applications

Unspecified application

Species

Unspecified reactive species

Ryuji Okamoto,Itaru Goto,Yuhei Nishimura,Issei Kobayashi,Ryotaro Hashizume,Yoshinori Yoshida,Rie Ito,Yuhko Kobayashi,Misato Nishikawa,Yusuf Ali,Shunsuke Saito,Toshio Tanaka,Yoshiki Sawa,Masaaki Ito,Kaoru Dohi
View all publications
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Product promise

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