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AB325667

Anti-ANK3 antibody [N106/36] - Chicken IgY (Chimeric)

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Chicken Monoclonal ANK-3 antibody. Suitable for IHC-P and reacts with Rat samples.

View Alternative Names

Ankyrin-3, ANK-3, Ankyrin-G

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ANK3 antibody [N106/36] - Chicken IgY (Chimeric) (AB325667)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ANK3 antibody [N106/36] - Chicken IgY (Chimeric) (AB325667)

Representative section of formalin fixed, paraffin-embedded rat brain cerebral cortex showing neurons stained by ab325667 at 1 : 500 dilution (green). The stained sections were mounted with Fluoroshield with DAPI and DABCO mounting medium. DAPI nuclear stain (blue) shows cell nuclei. The antibody specifically stains the neuronal cell body and axon initial segment (AIS) in the cerebral cortex. Mag. 100X.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ANK3 antibody [N106/36] - Chicken IgY (Chimeric) (AB325667)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ANK3 antibody [N106/36] - Chicken IgY (Chimeric) (AB325667)

Representative section of formalin fixed, paraffin-embedded rat brain cerebral cortex showing neurons stained by ab325667 at 1 : 500 dilution (green). The stained sections were mounted with Fluoroshield with DAPI and DABCO mounting medium. DAPI nuclear stain (blue) shows cell nuclei. The antibody specifically stains the neuronal cell body and axon initial segment (AIS) in the cerebral cortex. Mag. 400X.

Key facts

Host species

Chicken

Clonality

Monoclonal

Clone number

N106/36

Isotype

IgY

Carrier free

No

Reacts with

Rat

Applications

IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

Does not cross-react with Ankyrin-B.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Purification notes
This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N106/36 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N106/36 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media.
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (By similarity). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (By similarity). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (PubMed : 21617128).
See full target information Ank3
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Product promise

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