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AB64963

Anti-ANKRD1 antibody

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(4 Publications)

Rabbit Polyclonal ANKRD1 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human ANKRD1.

View Alternative Names

C193, CARP, HA1A2, ANKRD1, Ankyrin repeat domain-containing protein 1, Cardiac ankyrin repeat protein, Cytokine-inducible gene C-193 protein, Cytokine-inducible nuclear protein

1 Images
Western blot - Anti-ANKRD1 antibody (AB64963)
  • WB

Unknown

Western blot - Anti-ANKRD1 antibody (AB64963)

All lanes:

Western blot - Anti-ANKRD1 antibody (ab64963) at 1/500 dilution

Lane 1:

COLO205 cell extract at 5 µg

Lane 2:

COLO205 cell extract at 5 µg with immunising peptide

Predicted band size: 36 kDa

Observed band size: 36 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ANKRD1. The exact immunogen used to generate this antibody is proprietary information.

Q15327

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ANKRD1 also known as Ankyrin Repeat Domain 1 or CARP (Cardiac Ankyrin Repeat Protein) is a protein with a molecular weight of approximately 39 kDa. It is involved in cellular mechanics and is widely expressed in heart skeletal muscle and kidney tissues. ANKRD1 functions as a nuclear transcription factor and also binds to other cytoskeletal proteins influencing structural organization and cellular dynamics. Its presence is significant in muscle cells where it participates in responding to mechanical stress.
Biological function summary

ANKRD1 plays a role in the regulation of gene expression especially in the cardiovascular system. It interacts with muscle structural proteins and can form part of a complex with titin which is a giant protein essential for muscle flexibility and elasticity. ANKRD1 modulates muscle development and function by affecting the expression of genes linked to muscle growth and repair. It responds to mechanical stretch in muscles influencing transcriptional activity linked to adaptation and stress resistance.

Pathways

ANKRD1 is involved in the cardiac hypertrophy and muscle cell stress response pathways where its role in these processes is well documented. It interacts with proteins such as p53 contributing to pathways that manage cellular stress and damage response. ANKRD1 participates in signaling events that modify cardiovascular cell growth and survival and this involvement makes it significant in understanding cardiac remodeling and hypertrophic processes.

ANKRD1 is relevant to cardiomyopathy and muscular dystrophy. Abnormal expression or mutations in the ANKRD1 gene are linked to cardiomyopathy a disease where heart muscle becomes thick or weak. It has associations with other muscle regulatory proteins including dystrophin which plays a role in muscle integrity and is implicated in muscular dystrophy. These connections highlight ANKRD1’s importance in both normal cardiac function and in the pathogenesis of heart and muscle diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.
See full target information ANKRD1
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Clinical and translational medicine 15:e70123 PubMed39748197

2025

Titin gene mutations enhance radiotherapy efficacy via modulation of tumour immune microenvironment in rectum adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Hengchang Liu,Jialiang Liu,Xu Guan,Zhixun Zhao,Pu Cheng,Haipeng Chen,Zheng Jiang,Xishan Wang

British journal of pharmacology 179:4575-4592 PubMed35751875

2022

Riociguat attenuates the changes in left ventricular proteome and microRNA profile after experimental aortic stenosis in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Alexander Benkner,Julia Rüdebusch,Neetika Nath,Elke Hammer,Karina Grube,Stefan Gross,Vishnu M Dhople,Gertrud Eckstein,Thomas Meitinger,Lars Kaderali,Uwe Völker,Jens Fielitz,Stephan B Felix

Heliyon 4:e00514 PubMed29560432

2018

Altered regulation of cardiac ankyrin repeat protein in heart failure.

Applications

Unspecified application

Species

Unspecified reactive species

Amber Kempton,Matt Cefalu,Cody Justice,Tesla Baich,Mohamed Derbala,Benjamin Canan,Paul M L Janssen,Peter J Mohler,Sakima A Smith

Journal of molecular evolution 70:1-12 PubMed19967343

2009

The muscle ankyrin repeat proteins are hypoxia-sensitive: in vivo mRNA expression in the hypoxia-tolerant blind subterranean mole rat, Spalax ehrenbergi.

Applications

WB

Species

Rat

Mark Band,Alma Joel,Aaron Avivi
View all publications
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