Anti-ANKRD1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ANKRD1 also known as Ankyrin Repeat Domain 1 or CARP (Cardiac Ankyrin Repeat Protein) is a protein with a molecular weight of approximately 39 kDa. It is involved in cellular mechanics and is widely expressed in heart skeletal muscle and kidney tissues. ANKRD1 functions as a nuclear transcription factor and also binds to other cytoskeletal proteins influencing structural organization and cellular dynamics. Its presence is significant in muscle cells where it participates in responding to mechanical stress.

Biological function summary

ANKRD1 plays a role in the regulation of gene expression especially in the cardiovascular system. It interacts with muscle structural proteins and can form part of a complex with titin which is a giant protein essential for muscle flexibility and elasticity. ANKRD1 modulates muscle development and function by affecting the expression of genes linked to muscle growth and repair. It responds to mechanical stretch in muscles influencing transcriptional activity linked to adaptation and stress resistance.

Pathways

ANKRD1 is involved in the cardiac hypertrophy and muscle cell stress response pathways where its role in these processes is well documented. It interacts with proteins such as p53 contributing to pathways that manage cellular stress and damage response. ANKRD1 participates in signaling events that modify cardiovascular cell growth and survival and this involvement makes it significant in understanding cardiac remodeling and hypertrophic processes.

Associated diseases and disorders

ANKRD1 is relevant to cardiomyopathy and muscular dystrophy. Abnormal expression or mutations in the ANKRD1 gene are linked to cardiomyopathy a disease where heart muscle becomes thick or weak. It has associations with other muscle regulatory proteins including dystrophin which plays a role in muscle integrity and is implicated in muscular dystrophy. These connections highlight ANKRD1’s importance in both normal cardiac function and in the pathogenesis of heart and muscle diseases.