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AB151718

Anti-ANKRD2 antibody [EPR10731(B)]

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(1 Publication)

Rabbit Recombinant Monoclonal ANKRD2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication.

View Alternative Names

ARPP, ANKRD2, Ankyrin repeat domain-containing protein 2, Skeletal muscle ankyrin repeat protein, hArpp

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-ANKRD2 antibody [EPR10731(B)] (AB151718)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ANKRD2 antibody [EPR10731(B)] (AB151718)

Immunofluorescent analysis of HepG2 cells labeling ANKRD2 with ab151718 at 1/100 diluton.

Western blot - Anti-ANKRD2 antibody [EPR10731(B)] (AB151718)
  • WB

Unknown

Western blot - Anti-ANKRD2 antibody [EPR10731(B)] (AB151718)

All lanes:

Western blot - Anti-ANKRD2 antibody [EPR10731(B)] (ab151718) at 1/1000 dilution

All lanes:

Human skeletal muscle lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 37 kDa

false

  • Carrier free

    Anti-ANKRD2 antibody [EPR10731(B)] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR10731(B)

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9% PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ANKRD2 also known as Arpp and MARP2 is an ankyrin repeat protein with a molecular mass of approximately 36 kDa. It is mainly expressed in skeletal muscle and cardiac muscle tissues. The protein functions by interacting with other proteins contributing to muscle structure and function. ANKRD2 binds to titin a critical sarcomeric protein playing a role in muscle elasticity and integrity.
Biological function summary

ANKRD2 acts as a stretch sensor within muscle fibers. This role allows it to be part of a complex responsible for mediating mechanosignaling pathways that respond to mechanical stress or damage in muscle cells. ANKRD2 interacts with other signaling molecules like the transcription factor PML which modulates gene expression in response to mechanical cues.

Pathways

ANKRD2 participates in the muscle-specific mechanotransduction cascade. It plays a significant role in the modulation of MAPK signaling which is important for muscle growth and regeneration. The protein associates with other important proteins in this pathway such as titin and PML which work together to regulate muscle adaptation to physical stress.

ANKRD2 has an association with cardiomyopathy and muscular dystrophy. Its interactions with proteins such as titin and PML may influence the pathology of these diseases as these proteins are key in maintaining muscle and cardiac tissue stability. Disruption in ANKRD2 function or expression can contribute to muscular and cardiac impairments highlighting its importance in muscle-related conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress.
See full target information ANKRD2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

GeroScience 42:1157-1173 PubMed32578071

2020

Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity.

Applications

Unspecified application

Species

Unspecified reactive species

Natalia Mota-Martorell,Mariona Jove,Irene Pradas,Rebeca Berdún,Isabel Sanchez,Alba Naudi,Eloi Gari,Gustavo Barja,Reinald Pamplona
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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