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Rabbit Polyclonal Ankrd26 antibody. Suitable for WB and reacts with Transfected cell lysate, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Mouse Ankrd26 aa 1-50.

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Images

Western blot - Anti-Ankrd26 antibody (AB47984), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

Preservative: 0.01% Sodium azide
Constituents: 0.88% Sodium chloride, 0.424% Tripotassium orthophosphate

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Mouse Ankrd26 aa 1-50. The exact immunogen used to generate this antibody is proprietary information. Database link Q811D2

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested
Rat
Predicted
Transfected cell lysate
Tested

Tested
Tested

Species

Transfected cell lysate

Dilution info

-

Notes

-

Species

Human

Dilution info

1/500 - 1/3000

Notes

-

Predicted
Predicted

Species

Rat

Dilution info

-

Notes

-

Associated Products

Select an associated product type

2 products for Alternative Product

Target data

Function

Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior.

Alternative names

Recommended products

Rabbit Polyclonal Ankrd26 antibody. Suitable for WB and reacts with Transfected cell lysate, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Mouse Ankrd26 aa 1-50.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Synthetic Peptide within Mouse Ankrd26 aa 1-50. The exact immunogen used to generate this antibody is proprietary information. Database link Q811D2
Purification technique

Affinity purification Immunogen

Specificity

A BLAST analysis was used to suggest cross reactivity with Ankrd26 proteins from mouse (100%), rat (93%), bovine (81%) and human (68%). Reactivity against homologues from other sources is not known.

Concentration
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Purification notes

This affinity-purified antibody is directed against mouse Ankrd26 protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Ankrd26 also known as Ankyrin Repeat Domain 26 is a protein encoded by the ANKRD26 gene. It has a molecular mass of roughly 216 kDa. Ankrd26 is widely expressed in various tissues with prominent presence in hematopoietic tissues and the central nervous system. Its mechanical function involves interactions with other proteins through its ankyrin repeat domains enabling it to play a role in cellular structural and regulatory processes.

Biological function summary

Ankrd26 acts as a regulatory element involved in signaling pathways that control cell development and proliferation. It is part of protein complexes that regulate cytoskeletal organization impacting cell shape and mobility. This protein has important roles in hematopoietic stem cell function and differentiation influencing the generation of blood cell lineages. Ankrd26's ability to interact with various cellular partners suggests its involvement in broader biological mechanisms.

Pathways

Ankrd26 is implicated in the JAK-STAT signaling pathway and the PI3K-Akt pathway. These pathways oversee cell growth survival and differentiation highlighting Ankrd26's important regulatory nature. Ankrd26 interacts with proteins such as JAK2 and Akt emphasizing its integration into these cellular pathways. This crosstalk allows Ankrd26 to modulate cellular responses to various external signals and maintain cellular homeostasis.

Associated diseases and disorders

Ankrd26 has associations with thrombocytopenia and certain cancers. Thrombocytopenia relates to mutations in the ANKRD26 gene that impair normal hematopoietic cell function affecting blood platelet levels. Additionally altered expression or mutation of Ankrd26 can contribute to oncogenesis linking it to cancer pathways. Interactions between Ankrd26 and proteins like JAK2 in these contexts underline the importance of this protein in maintaining health and its potential role in disease.

Product promise

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1 product image

  • Western blot - Anti-Ankrd26 antibody (ab47984), expandable thumbnail

    Western blot - Anti-Ankrd26 antibody (ab47984)

    Detection of endogenous Ankrd26 protein in MES cell
    lysates may occur when detection methods with higher
    sensitivity are used. An observed band of ~81kDa has been obtained due to a fragment of Ankrd26 being used instead of the full length version.

    Lane 1: Western blot - Anti-Ankrd26 antibody (ab47984)

    Lanes 10, 2, 3, 4, 5, 6, 7, 8 and 9: Western blot - Anti-Ankrd26 antibody (ab47984) at 1/1000 dilution

    Lane 1: BLANK

    Lane 2: MES cell lysate - 80µg

    Lane 3: MES cell lysate - 40µg

    Lane 4: 293T-ANKRD26transfected cell lysate - 20µg

    Lane 5: control 293T celllysate - 20µg

    Lane 6: BSA-ANKRD26 conjugate - 20ng

    Lane 7: BSA - 500ng

    Lane 8: BSA - 100ng

    Lane 9: BSA - 20ng

    Lane 10: Protein standards

    Secondary

    All lanes: ALP conjugated Gt-a-Rabbit IgG at 1/3000 dilution

    Predicted band size: 196 kDa

    Observed band size: 81 kDa

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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