AB137424

Anti-Annexin-11/ANXA11 antibody

Name: Anti-Annexin-11/ANXA11 antibody (ab137424) | Abcam
Brand: Abcam Limited
SKU: AB137424

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(2 Publications)

Rabbit Polyclonal Annexin-11/ANXA11 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ANXA11 aa 1 to C-terminus.

View Alternative Names

ANX11, ANXA11, Annexin A11, 56 kDa autoantigen, Annexin XI, Annexin-11, Calcyclin-associated annexin 50, CAP-50

1 Images

Supplier Data

Western blot - Anti-Annexin-11/ANXA11 antibody (AB137424)

Samples were separated by 10% SDS-PAGE. Corresponding RNA expression data for the same cell lines are based on Human Protein Atlas program.

All lanes:

Western blot - Anti-Annexin-11/ANXA11 antibody (ab137424) at 1/1000 dilution

Lane 1:

293T whole cell extracts at 30 µg

Lane 2:

A431 whole cell extracts at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Fragment Protein within Human ANXA11 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P50995

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Annexin-11 also known as ANXA11 or annexin A11 is a calcium-dependent phospholipid-binding protein with a molecular mass of approximately 56 kDa. It belongs to the annexin family and functions through interactions with membrane phospholipids in a calcium-dependent manner. Annexin A11 is expressed in various tissues including the brain liver and spleen. Molecularly annexin A11 participates in vesicle trafficking endocytosis and the regulation of cell division by interacting with the mitotic spindle apparatus.

Biological function summary

Annexin A11 plays a significant role in cellular processes such as membrane repair cell migration and apoptosis. It does not form a stable part of a large protein complex under normal conditions but interacts dynamically with other proteins during cellular events. This protein influences intracellular calcium signaling which is important for maintaining cellular homeostasis and responding to extracellular stimuli. Annexin A11 regulates actin cytoskeletal organization impacting cell motility and structural integrity.

Pathways

Annexin A11’s functions integrate into critical cell signaling and communication pathways such as the calcium signaling pathway and apoptosis pathway. Within these pathways annexin A11 interacts with other proteins like annexin V and annexin II modifying intracellular responses to calcium fluctuations and apoptotic signals. These pathways ensure proper cellular responses to environmental changes and stress conditions facilitating processes like cell survival and programmed cell death.

Annexin A11 associates with amyotrophic lateral sclerosis (ALS) and certain types of cancer. Mutations in the ANXA11 gene correlate with the development of familial ALS where annexin A11 dysfunction affects neuronal survival and leads to motor neuron degeneration. In certain cancers elevated levels of annexin A11 may influence tumor growth through its role in cell proliferation pathways. In both ALS and cancer proteins such as SOD1 in ALS and cyclin D1 in cancer may have connections to annexin A11’s function and regulatory networks.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.

See full target information ANXA11

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

American journal of cancer research 10:12-37 PubMed32064151

2020

Pancreatic cancer-derived small extracellular vesical Ezrin regulates macrophage polarization and promotes metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Ting Chang,Hsuan-Yu Peng,Chun-Mei Hu,Shih-Chia Huang,Sui-Chi Tien,Yung-Ming Jeng

Human molecular genetics 22:4871-87 PubMed23851121

2013

Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.

Applications

Unspecified application

Species

Unspecified reactive species

Suzana Gispert,Dajana Parganlija,Michael Klinkenberg,Stefan Dröse,Ilka Wittig,Michel Mittelbronn,Pawel Grzmil,Sebastian Koob,Andrea Hamann,Michael Walter,Finja Büchel,Thure Adler,Martin Hrabé de Angelis,Dirk H Busch,Andreas Zell,Andreas S Reichert,Ulrich Brandt,Heinz D Osiewacz,Marina Jendrach,Georg Auburger

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Annexin-11/ANXA11 antibody

Western blot - Anti-Annexin-11/ANXA11 antibody (AB137424)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Product promise