JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB88539

Anti-Annexin-7/ANXA7 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Mouse Polyclonal Annexin-7/ANXA7 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ANXA7.

View Alternative Names

ANX7, SNX, OK/SW-cl.95, ANXA7, Annexin A7, Annexin VII, Annexin-7, Synexin

4 Images
Immunocytochemistry/ Immunofluorescence - Anti-Annexin-7/ANXA7 antibody (AB88539)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Annexin-7/ANXA7 antibody (AB88539)

ab88539, at 10 μg/ml, staining ANXA7 in Hela cells by Immunofluorescence.

Western blot - Anti-Annexin-7/ANXA7 antibody (AB88539)
  • WB

Unknown

Western blot - Anti-Annexin-7/ANXA7 antibody (AB88539)

All lanes:

Western blot - Anti-Annexin-7/ANXA7 antibody (ab88539) at 1 µg/mL

All lanes:

Hela cell lysate at 50 µg

Predicted band size: 53 kDa

Observed band size: 50 kDa

false

Western blot - Anti-Annexin-7/ANXA7 antibody (AB88539)
  • WB

Unknown

Western blot - Anti-Annexin-7/ANXA7 antibody (AB88539)

All lanes:

Western blot - Anti-Annexin-7/ANXA7 antibody (ab88539) at 1 µg/mL

Lane 1:

ANXA7 transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Predicted band size: 53 kDa

Observed band size: 46 kDa

false

Western blot - Anti-Annexin-7/ANXA7 antibody (AB88539)
  • WB

Unknown

Western blot - Anti-Annexin-7/ANXA7 antibody (AB88539)

All lanes:

Western blot - Anti-Annexin-7/ANXA7 antibody (ab88539) at 1 µg/mL

All lanes:

human liver tissue lysate at 50 µg

Predicted band size: 53 kDa

Observed band size: 43 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ANXA7.

P20073

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Annexin-7 (ANXA7) also known as synexin is a calcium-dependent phospholipid-binding protein. It has a molecular weight of approximately 51 kDa. This protein is expressed in various tissues with notable expression in the heart and brain. Mechanically ANXA7 plays a role in membrane fusion and exocytosis which are critical processes for cellular communication and transport.
Biological function summary

Annexin-7 functions as an important player in cell proliferation and signal transduction. It forms part of the annexin family of proteins which are known for their role in calcium ion binding and membrane-related activities. Annexin-7 has a role in linking Ca2+ signaling with phospholipid membrane dynamics which suggests its involvement in cellular events like growth and differentiation.

Pathways

Annexin-7 influences both the MAPK and EGFR signaling pathways. These pathways are essential for regulating cell division apoptosis and cellular response to external stimuli. Within these pathways Annexin-7 interacts with proteins such as Ras and PI3K which are important for propagating signals that control cellular behaviors.

Abnormalities in Annexin-7 expression and function associate it with cancer and schizophrenia. In cancer altered ANXA7 function may disrupt normal cell communication and growth pathways contributing to tumorigenesis. In schizophrenia disrupted calcium signaling involving ANXA7 may affect neuronal communication and brain function. In these conditions Annexin-7 interacts with proteins like p53 and NMDA receptors which are critical to the pathology of cancer and neurological disorders respectively.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.
See full target information ANXA7
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in physiology 10:143 PubMed30863317

2019

Dynamin Binding Protein Is Required for Kidney Development.

Applications

Unspecified application

Species

Unspecified reactive species

Bridget D DeLay,Tanya A Baldwin,Rachel K Miller
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB197586

Anti-Annexin-7/ANXA7 antibody [EPR17090]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Annexin-7/ANXA7 antibody [EPR17090] (AB197586)

  • 0
  • 0
Primary Antibodies

AB198990

Anti-Annexin-7/ANXA7 antibody [EPR16173] - N-terminal

RabMAb|Recombinant

Western blot - Anti-Annexin-7/ANXA7 antibody [EPR16173] - N-terminal (AB198990)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB125011

Anti-TSG101 antibody [EPR7130(B)]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry - Anti-TSG101 antibody [EPR7130(B)] (AB125011)

  • 4
  • 10
Primary Antibodies

AB275377

Anti-ALIX antibody [EPR23653-32]

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-ALIX antibody [EPR23653-32] (AB275377)

  • 5
  • 2
Primary Antibodies

AB79202

Anti-Caspase-9 (phospho Y153) antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Caspase-9 (phospho Y153) antibody (AB79202)

  • 0
  • 0
Primary Antibodies

AB133633

Anti-Carcino Embryonic Antigen CEA antibody [EPCEAR7]

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Carcino Embryonic Antigen CEA antibody [EPCEAR7] (AB133633)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com