Anti-Annexin-9/ANXA9 antibody [EPR11220]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Annexin-9 (ANXA9) acts as a calcium/phospholipid-binding protein and belongs to the annexin family characterized by their dependency on calcium for membrane binding. ANXA9 has a molecular mass of about 36 kDa. It expresses in epithelial tissues particularly within the skin esophagus and the major airways suggesting its role in cellular homeostasis and communication in these areas. ANXA9's structure includes typical annexin repeats responsible for its binding properties and it shares similarities with other annexins.

Biological function summary

ANXA9 participates in membrane-related processes such as vesicle trafficking and membrane organization. It engages in forming stable complexes with other annexin proteins enhancing their collective functions involved in cell signaling or membrane dynamics. The protein localizes near cell membranes and aids in mediating cell-cell interactions signifying its involvement in maintaining cellular environments.

Pathways

ANXA9 connects with signaling pathways that are important for phospholipid metabolism and membrane trafficking. It interacts with proteins like ANXA1 and ANXA2 which also belong to the annexin family and perform overlapping functions in modulating cellular responses to extracellular signals. Understanding its precise role in these pathways can provide insights into its influence on cell surface receptor-mediated signaling and lipid-related metabolic processes.

Associated diseases and disorders

Studies link ANXA9 with certain epithelial cancers given its pattern of expression in epithelial tissues. Its abnormal regulation may associate with tumor growth or progression due to its role in cell membrane stability and signal transduction. Additionally ANXA9 is associated with skin disorders where it might interact with proteins such as filaggrin contributing to barrier dysfunctions or inflammatory responses. These connections highlight the need for further research to elucidate ANXA9’s exact functions and its potential as a therapeutic target in these conditions.