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AB239582

Anti-Annexin A3/ANXA3 antibody [6#]

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(1 Publication)

Mouse Monoclonal Annexin A3/ANXA3 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ANXA3 aa 1-200.

View Alternative Names

ANX3, ANXA3, Annexin A3, 35-alpha calcimedin, Annexin III, Annexin-3, Lipocortin III, Placental anticoagulant protein III, PAP-III

2 Images
Western blot - Anti-Annexin A3/ANXA3 antibody [6#] (AB239582)
  • WB

Supplier Data

Western blot - Anti-Annexin A3/ANXA3 antibody [6#] (AB239582)

All lanes:

Western blot - Anti-Annexin A3/ANXA3 antibody [6#] (ab239582) at 3 µg/mL

Lane 1:

Human lung tissue lysate

Lane 2:

HepG2 (human liver hepatocellular carcinoma cell line) cell lysate

Secondary

All lanes:

HRP-linked Rabbit anti-Mouse IgG at 1/5000 dilution

Predicted band size: 36 kDa

Observed band size: 35 kDa

false

Western blot - Anti-Annexin A3/ANXA3 antibody [6#] (AB239582)
  • WB

Supplier Data

Western blot - Anti-Annexin A3/ANXA3 antibody [6#] (AB239582)

All lanes:

Western blot - Anti-Annexin A3/ANXA3 antibody [6#] (ab239582) at 5 µg/mL

All lanes:

Human Recombinant Annexin A3/ANXA3 protein

Predicted band size: 36 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

6#

Isotype

IgG2a

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human ANXA3 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

P12429

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Purification notes
Purified from TCS.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Annexin A3 also known as ANXA3 is a 36 kDa protein that belongs to the annexin family. This family is known for calcium-dependent phospholipid-binding activity. ANXA3 specifically binds to phosphatidylserine a type of phospholipid found in cell membranes. It is expressed in various tissues with notable presence in myeloid cells particularly in the bone marrow and granulocytes.
Biological function summary

ANXA3 plays roles in membrane-related events including vesicle trafficking and exocytosis. It is not part of a large complex but associates with other proteins depending on its cellular function. ANXA3 can also regulate inflammation by modulating macrophage activation and may influence signal transduction pathways that are linked to immune responses.

Pathways

ANXA3 functions in both inflammation and apoptosis. It is closely related to the apoptosis pathway by interacting with signaling molecules like caspases which are critical for the execution of cell death. Additionally through its action in the inflammation pathway ANXA3 is known to interact with proteins such as NF-κB an important regulator of immune and inflammatory responses.

Alterations in ANXA3 expression or function associate with various conditions most notably cancer and autoimmune diseases. For instance in certain cancers ANXA3 may contribute to tumor growth and metastasis. In autoimmune diseases its regulation of macrophage activity can misbalance immune responses leading to pathogenesis. Proteins such as ANXA1 and S100A11 also play roles in these pathways and may function along with ANXA3 in disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.
See full target information ANXA3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of orthopaedic surgery and research 20:835 PubMed40999516

2025

Neuregulin 4 inhibits synovial macrophage pro-inflammatory polarization via ErbB4/Stat5b/NF-κB signaling to alleviate osteoarthritis progression.

Applications

Unspecified application

Species

Unspecified reactive species

Daoliang Jiang,Xiaoli Xu,Wenjing Yang,Mengjia Tang,Yuping Zhang,Lingfeng Shi,Jiongyu Hu
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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