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AB181663

Anti-anoctamin 5 antibody

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(3 Publications)

Rabbit Polyclonal anoctamin 5 antibody. Suitable for ELISA, WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ANO5 aa 750-850.

View Alternative Names

GDD1, TMEM16E, ANO5, Anoctamin-5, Gnathodiaphyseal dysplasia 1 protein, Transmembrane protein 16E

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ELISA, WB

applications

Immunogen

Synthetic Peptide within Human ANO5 aa 750-850. The exact immunogen used to generate this antibody is proprietary information.

Q75V66

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Reactivity data

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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Anoctamin 5 also known as ANO5 or TMEM16E is a protein that functions as a calcium-activated chloride channel. It plays a role in phospholipid scramblase activity. Anoctamin 5 is a member of the anoctamin family characterized by ten transmembrane domains. The protein has a molecular mass of approximately 114 kDa. It is expressed in various tissues with notable presence in skeletal muscle cardiac muscle and bone.
Biological function summary

Anoctamin 5 contributes to the regulation of muscle membrane integrity and bone mineralization. It does not function in isolation; it associates with other proteins to maintain the structure and function of muscle cells. In skeletal muscle Anoctamin 5 impacts sarcolemmal repair. In bones it influences the mineralization process by regulating the balance of calcium ions. The protein indirectly affects cell adhesion and signaling by modulating ion channel function.

Pathways

Anoctamin 5 engages in the muscle repair and mineralization pathways. It plays a part in the sarcolemmal repair pathway working closely with dysferlin another protein involved in muscle cell membrane repair. Anoctamin 5’s activity in ion transport is important for maintaining ionic homeostasis during muscle stress and repair events. In the bone mineralization pathway it influences the availability of calcium ions affecting bone density and strength.

Anoctamin 5 mutations have been linked to conditions such as limb-girdle muscular dystrophy type 2L (LGMD2L) and Miyoshi muscular dystrophy type 3 (MMD3). These are genetic disorders characterized by progressive muscle weakness due to impaired muscle membrane repair. The relationship between Anoctamin 5 and these disorders highlights its importance in muscle integrity. In these diseases anomalies in Anoctamin 5 expression or function can disrupt pathways shared with dysferlin exacerbating muscle deterioration.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in plasma membrane repair in a process involving annexins (PubMed : 33496727). Does not exhibit calcium-activated chloride channel (CaCC) activity.
See full target information ANO5
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:112302 PubMed40641552

2025

Humanized mouse model reveals T cell ANXA2 as a potential therapeutic target in ischemic stroke.

Applications

Unspecified application

Species

Unspecified reactive species

Tianyuan Zhang,Xiaojuan Zheng,Aijun Lu,Shuyuan Li,Keshen Li,Xiaoxiong Huang,Yanfang Liu,Wei Chen,Shengming Huang,Niu He,Chi Kwan Tsang,Hongcheng Mai,Anding Xu,Dan Lu

International journal of clinical and experimental 12:4263-4270 PubMed31933826

2019

Anoctamin 5 regulates cell proliferation and migration in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Hai-Yan Song,Li Zhou,Xin-Fang Hou,Hui Lian

Neuropathology and applied neurobiology 44:441-448 PubMed28489263

2017

Diagnostic anoctamin-5 protein defect in patients with ANO5-mutated muscular dystrophy.

Applications

Unspecified application

Species

Unspecified reactive species

A Vihola,H Luque,M Savarese,S Penttilä,M Lindfors,F Leturcq,B Eymard,G Tasca,B Brais,T Conte,K Charton,I Richard,B Udd
View all publications
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