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AB196675

Anti-Anoctamin 7 antibody - C-terminal

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(1 Publication)

Rabbit Polyclonal Anoctamin 7 antibody. C-terminal. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ANO7.

View Alternative Names

NGEP, PCANAP5, TMEM16G, ANO7, Anoctamin-7, Dresden transmembrane protein of the prostate, IPCA-5, New gene expressed in prostate, Prostate cancer-associated protein 5, Transmembrane protein 16G, D-TMPP

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Anoctamin 7 antibody - C-terminal (AB196675)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Anoctamin 7 antibody - C-terminal (AB196675)

Immunohistochemical analysis of paraffin-embedded Human prostate carcinoma tissue labeling Anoctamin 7 with ab196675 at 1/50 dilution, in the presence (right panel) or absence (left panel) of immunizing peptide.

Immunocytochemistry/ Immunofluorescence - Anti-Anoctamin 7 antibody - C-terminal (AB196675)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Anoctamin 7 antibody - C-terminal (AB196675)

Immunofluorescent analysis of HepG2 cells labeling Anoctamin 7 with ab196675 at 1/100 dilution, in the presence (right panel) or absence (left panel) of immunizing peptide.

Western blot - Anti-Anoctamin 7 antibody - C-terminal (AB196675)
  • WB

Supplier Data

Western blot - Anti-Anoctamin 7 antibody - C-terminal (AB196675)

All lanes:

Western blot - Anti-Anoctamin 7 antibody - C-terminal (ab196675) at 1/500 dilution

Lane 1:

LOVO cell extract

Lane 2:

LOVO cell extract with immunizing peptide

Predicted band size: 106 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF, WB

applications

Immunogen

Synthetic Peptide within Human ANO7. The exact immunogen used to generate this antibody is proprietary information.

Q6IWH7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab196675 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Anoctamin 7 also known as ANO7 or TMEM16G is a transmembrane protein that belongs to the anoctamin family. It functions as a calcium-activated chloride channel with a role in ion transport. Anoctamin 7 has a molecular weight of approximately 120 kDa. The protein is expressed in many tissues with high levels in the prostate suggesting a specialized function in this organ.
Biological function summary

ANO7 influences important cellular processes like fluid secretion cell volume regulation and signal transduction. It is a component of a larger protein complex involved in calcium signaling which impacts various physiological functions. In the prostate ANO7 expression may influence normal prostate function and development indicating a possible role in prostate-specific tasks.

Pathways

ANO7 participates in important pathways like calcium-dependent regulation of ion transport and signal transduction through chloride channels. It interacts with proteins such as ANO1 and ANO2 within these pathways sharing similar chloride channel functions. These interactions are necessary for maintaining ion balance and signaling across cell membranes impacting general cellular homeostasis.

ANO7's expression has been linked to prostate cancer where abnormalities in its function may influence disease development or progression. The protein is also associated with disorders related to ion transport potentially due to its role in chloride channel regulation. Research on ANO7 interactions with other proteins like ANO1 might reveal further insights into its contribution to these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed : 22075693). May play a role in cell-cell interactions (PubMed : 17308099).
See full target information ANO7
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

British journal of pharmacology 181:3760-3778 PubMed38872396

2024

Factor XII and prekallikrein promote microvascular inflammation and psoriasis in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yurong Zhang,Zengrong Chen,Junyan Guo,Qing Wan,Yingjie Zhang,Huihui Li,Haojie Rao,Jianfeng Yang,Pengfei Xu,Hong Chen,Miao Wang
View all publications
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Product promise

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