Anti-ANP32C/PP32R1 antibody [EPR13354] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ANP32C also known as PP32R1 is a protein with a mass of approximately 30 kDa. It belongs to the acidic nuclear phosphoprotein 32 kDa family and plays mechanical roles in several cellular processes. ANP32C localizes mainly in the nucleus and shows expression in various tissues with notable presence in the brain and peripheral blood. Its functions involve interactions with other proteins to regulate cellular processes making it a significant target for research in cellular biology.

Biological function summary

ANP32C influences multiple cellular events including regulation of gene expression apoptosis and chromatin modification. It is part of several multiprotein complexes which contribute to its role in transcriptional regulation and cell cycle progression. The interaction of ANP32C with histone acetyltransferases plays a significant role in chromatin remodeling affecting gene expression patterns. This protein's actions are critical for maintaining normal cellular functions and responding to stress conditions.

Pathways

ANP32C engages in the apoptotic and inflammatory signaling pathways. It associates with proteins such as caspases and NF-kappa B influencing cell survival and immune responses. ANP32C's participation in the apoptotic pathway reflects its role in regulating programmed cell death a fundamental process for tissue homeostasis and development. Its interaction with inflammatory mediators highlights its contribution to immune responses and potential implications in inflammatory conditions.

Associated diseases and disorders

ANP32C has connections to cancer and neurodegenerative diseases. Abnormal expression or mutation of ANP32C correlates with increased proliferation in some cancers emphasizing its role in tumorigenesis. Additionally the protein links with tau pathology implicating it in neurodegenerative disorders such as Alzheimer's disease. These associations suggest that ANP32C along with interacting proteins like tau may serve as potential therapeutic targets for disease intervention strategies.