Rabbit Recombinant Monoclonal Thioredoxin 2 antibody - conjugated to Alkaline Phosphatase.
pH: 7.4
Preservative: 0.1% Proclin 300 Solution
Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA, 0.016% Magnesium chloride, 0.001% Zinc chloride
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
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Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.
TRX2, TXN2, MTRX, Mt-Trx, Thioredoxin-2
Rabbit Recombinant Monoclonal Thioredoxin 2 antibody - conjugated to Alkaline Phosphatase.
pH: 7.4
Preservative: 0.1% Proclin 300 Solution
Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA, 0.016% Magnesium chloride, 0.001% Zinc chloride
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Thioredoxin 2 also known as TXN2 is a protein that functions mainly as an oxidoreductase. It facilitates the reduction of other proteins through cysteine thiol-disulfide exchange which is important for maintaining cellular redox balance. This protein exists in the mitochondria where it is expressed ubiquitously across tissues. Thioredoxin 2 has a molecular mass of approximately 18 kDa. The presence of TXN2 in all cellular compartments suggests its importance in various cellular processes involving oxidative stress response.
Thioredoxin 2 participates in regulating mitochondrial redox homeostasis ensuring the protection of mitochondrial DNA against oxidative damage. It acts as a part of the mitochondrial thioredoxin system which includes thioredoxin reductase and NADPH as components. This system is important for the control of mitochondrial reactive oxygen species (ROS) and supports mitochondrial function by facilitating the synthesis of deoxyribonucleotides. The protein therefore plays an important role in cellular antioxidant defenses and in modulating mitochondrial apoptotic pathways.
The involvement of Thioredoxin 2 is pivotal in several cellular signaling cascades including the antioxidant defense and apoptosis pathways. Within the redox signaling pathways TXN2 works in conjunction with cytochrome c and caspases to regulate apoptosis and prevent uncontrolled cell death. In pathways related to cellular oxidative stress Thioredoxin 2 interacts closely with glutathione to mediate cellular responses to oxidative damage maintaining balance between the production and removal of ROS.
The dysregulation of Thioredoxin 2 correlates with various human conditions such as cancer and neurodegenerative diseases. In cancer alterations in TXN2 levels can affect cell survival and proliferation often by interacting with other antioxidant proteins like peroxiredoxins. For neurodegenerative diseases an imbalance in Thioredoxin 2 activity contributes to neuronal damage through disrupted oxidative stress regulation. This highlights TXN2's potential as a therapeutic target for disorders connected to oxidative stress imbalances.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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