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Mouse Polyclonal AP1M1 antibody. Suitable for WB and reacts with Human, Recombinant fragment - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AP-1 complex subunit mu-1 aa 1-100.

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Images

Western blot - Anti-AP1M1 antibody (AB194384), expandable thumbnail
  • Western blot - Anti-AP1M1 antibody (AB194384), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Mouse

Storage buffer

Constituents: 50% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human AP-1 complex subunit mu-1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BXS5

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested
Mouse
Predicted
Rat
Predicted
Cow
Predicted
Recombinant fragment - Human
Tested

Tested
Tested

Species

Human

Dilution info

1/500 - 1/1000

Notes

-

Species

Recombinant fragment - Human

Dilution info

1/500 - 1/1000

Notes

-

Predicted
Predicted

Species

Mouse, Rat, Cow

Dilution info

-

Notes

-

Associated Products

Select an associated product type

1 product for Alternative Product

Target data

Function

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Alternative names

Recommended products

Mouse Polyclonal AP1M1 antibody. Suitable for WB and reacts with Human, Recombinant fragment - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AP-1 complex subunit mu-1 aa 1-100.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human AP-1 complex subunit mu-1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BXS5
Purity

Whole antiserum

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

AP1M1 also known as Adaptor-related Protein Complex 1 Mu 1 Subunit is a protein with a molecular mass of around 50 kDa. AP1M1 functions as a component of the adaptor protein complex 1 (AP-1). It plays an essential mechanical role in sorting and trafficking proteins by mediating the selection of cargo molecules for transport vesicles. This protein is expressed in multiple tissues with particularly high levels noted in neuronal cells.

Biological function summary

AP1M1 serves as a critical link in intracellular transport processes. It is part of the AP-1 complex which consists of other subunits like gamma beta and sigma. These complexes work together to ensure proteins move correctly within the cell especially between the trans-Golgi network and endosomes. AP1M1 assists in clathrin-mediated trafficking playing an important role in maintaining cellular functionality by organizing the delivery of membrane proteins and other cellular components.

Pathways

AP1M1 integrates into the clathrin-coated vesicle pathway and the endocytic pathway. It cooperates with proteins such as clathrin and adaptins including other AP complexes to facilitate the formation of transport vesicles. These pathways are pivotal for protein sorting and the regulation of cellular homeostasis contributing to processes such as receptor recycling and lysosomal enzyme targeting.

Associated diseases and disorders

Mutations or dysfunction in AP1M1 are linked with neurodegenerative diseases like Alzheimer's disease and some cancers. AP1M1's interaction with proteins like tau in Alzheimer’s illustrates its importance in neurological pathways and synaptic health. In cancer improper protein sorting due to AP1M1 malfunction may influence metastatic behavior as it is connected to proteins involved in cell growth and division.

Product promise

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2 product images

  • Western blot - Anti-AP1M1 antibody (ab194384), expandable thumbnail

    Western blot - Anti-AP1M1 antibody (ab194384)

    Predicted MW of immunogen: 34.25 KDa

    All lanes: Western blot - Anti-AP1M1 antibody (ab194384) at 1/1000 dilution

    All lanes: recombinant human AP1M1 (immunogen) at 0.2 µg

    Predicted band size: 32 kDa, 49 kDa

  • Western blot - Anti-AP1M1 antibody (ab194384), expandable thumbnail

    Western blot - Anti-AP1M1 antibody (ab194384)

    All lanes: Western blot - Anti-AP1M1 antibody (ab194384) at 1/500 dilution

    All lanes: U-2 OS cell lysate at 50 µg

    Predicted band size: 49 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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