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Rabbit Polyclonal AP1S3 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human AP1S3.

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Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Full Length Protein corresponding to Human AP1S3. Database link Q96PC3
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested

Tested
Tested

Species

Human

Dilution info

10 µg/mL

Notes

-

Target data

Function

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking (PubMed:24791904).

Alternative names

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Rabbit Polyclonal AP1S3 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human AP1S3.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Full Length Protein corresponding to Human AP1S3. Database link Q96PC3
Purification technique

Precipitation Caprylic Acid and Ammonium Sulphate

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

Biological function summary

AP1S3 takes part in the vesicle-mediated transport process by participating in the AP-1 complex. This complex is important for the proper functioning of the trans-Golgi network and endosomal pathways. AP1S3 helps in the recruitment of clathrin and cargo selection which impacts vesicle formation. The protein interacts with other AP-1 complex components to ensure specific cargo recognition.

Activity summary

AP1S3 also known as adaptin protein complex 1 sigma 3 is a subunit of the adaptor protein complex 1 (AP-1) which plays a role in the trafficking of proteins within cells. This protein has a mass around 19 kDa. It is expressed in various tissues including the skin and immune cells. AP1S3 is involved in the sorting and packaging of cargo proteins influencing their movement to different cellular compartments.

Pathways

AP1S3 influences cellular protein trafficking mechanisms such as clathrin-mediated vesicular transport and endocytosis. It connects to the Golgi apparatus and endosomal-lysosomal systems integrating with proteins like clathrin and accessory proteins. These interactions place AP1S3 within pathways important for maintaining cellular protein homeostasis.

Associated diseases and disorders

AP1S3 associates with conditions such as pustular psoriasis and inflammatory responses. Mutations in AP1S3 disrupt normal cellular trafficking contributing to disease mechanisms. The protein connects to other immunological proteins such as TNF (Tumor Necrosis Factor) which plays a role in inflammation pathways associated with immune-related disorders.

Product promise

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2 product images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AP1S3 antibody (ab205509), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AP1S3 antibody (ab205509)

    Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human adrenal tissue labeling AP1S3 with ab205509 at 10μg/mL.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AP1S3 antibody (ab205509), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AP1S3 antibody (ab205509)

    Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human small intestine tissue labeling AP1S3 with ab205509 at 10μg/mL.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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