AB203691

Anti-AP2 gamma/TFAP2C antibody

Name: Anti-AP2 gamma/TFAP2C antibody (ab203691) | Abcam
Brand: Abcam Limited
SKU: AB203691
Rating: 5 (2 reviews)

(2 Reviews)

(1 Publication)

Rabbit Polyclonal AP2 gamma/TFAP2C antibody. Suitable for IHC-P and reacts with Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Transcription factor AP-2 gamma aa 1-50 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Transcription factor AP-2 gamma, AP2-gamma, Activating enhancer-binding protein 2 gamma, Transcription factor ERF-1, TFAP2C

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AP2 gamma/TFAP2C antibody (AB203691)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AP2 gamma/TFAP2C antibody (AB203691)

Immunohistochemical analysis of formalin-fixed and paraffin embedded rat brain labeling AP2 gamma/TFAP2C with ab203691 at 1/200 followed by conjugation to the secondary antibody and DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AP2 gamma/TFAP2C antibody (AB203691)

Immunohistochemical analysis of formalin-fixed and paraffin embedded mouse embryo labeling AP2 gamma/TFAP2C with ab203691 at 1/200 followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human Transcription factor AP-2 gamma aa 1-50 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q92754

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>For use with a fluorescent probe use at 1/50 -1/200</p>" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>For use with a fluorescent probe use at 1/50 -1/200</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AP2 gamma also known as TFAP2C functions as a transcription factor and belongs to the AP-2 family. AP2 gamma has a molecular weight of approximately 50 kDa. It regulates gene expression by binding to DNA sequence-specific sites influencing diverse cellular processes. This protein commonly expresses in tissues like mammary glands and is important in embryonic development. TFAP2C plays a role in differentiation and development across different cell types.

Biological function summary

AP2 gamma acts as a significant regulator of gene networks that control cell growth and differentiation. This protein contributes to transcriptional activation and repression often functioning within multiprotein complexes. It regulates the expression of genes involved in epithelial cell differentiation and morphogenesis. Importantly TFAP2C helps in the development of ectodermal tissues supporting cellular behaviors necessary for proper tissue formation.

Pathways

TFAP2C is involved in pathways that include developmental processes and differentiation. In particular it takes part in the Wnt signaling pathway influencing gene expression patterns that govern development. AP2 gamma interacts with proteins such as beta-catenin within the Wnt pathway modulating cell fate and proliferation. Another important pathway is the estrogen receptor signaling pathway where TFAP2C partners with proteins like ERα to regulate hormone-responsive genes.

AP2 gamma has links to breast cancer and neural tube defects. In breast cancer TFAP2C modulates genes associated with cancer progression and treatment response interacting with proteins like HER2. Mutations or dysregulation of TFAP2C can also lead to developmental anomalies like neural tube defects possibly due to altered gene expression during embryonic development. Understanding these connections provides insight into therapeutic strategies and developmental biology.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

See full target information Transcription factor AP-2 gamma

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular medicine 43:1939-1950 PubMed30864685

2019

GNG7 silencing promotes the proliferation and differentiation of placental cytotrophoblasts in preeclampsia rats through activation of the mTOR signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wei-Si Lai,Yi-Ling Ding

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-AP2 gamma/TFAP2C antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AP2 gamma/TFAP2C antibody (AB203691)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AP2 gamma/TFAP2C antibody (AB203691)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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