Rabbit Polyclonal AP2 gamma/TFAP2C antibody. Suitable for IHC-P and reacts with Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Transcription factor AP-2 gamma aa 1-50 conjugated to Keyhole Limpet Haemocyanin.
Images
Publications
Filter by
- International journal of molecular medicine 43:1939-19502019GNG7 silencing promotes the proliferation and differentiation of placental cytotrophoblasts in preeclampsia rats through activation of the mTOR signaling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWei-Si Lai et. al.PubMed 30864685
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human Transcription factor AP-2 gamma aa 1-50 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q92754
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Predicted |
| Mouse | Tested |
| Rat | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/100.00000 - 1/500.00000 | Notes For use with a fluorescent probe use at 1/50 -1/200 |
Species Rat | Dilution info 1/100.00000 - 1/500.00000 | Notes For use with a fluorescent probe use at 1/50 -1/200 |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
Associated Products
Select an associated product type
3 products for Alternative Product
Target data
Function
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Alternative names
Transcription factor AP-2 gamma, AP2-gamma, Activating enhancer-binding protein 2 gamma, Transcription factor ERF-1, TFAP2C
Recommended products
Rabbit Polyclonal AP2 gamma/TFAP2C antibody. Suitable for IHC-P and reacts with Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Transcription factor AP-2 gamma aa 1-50 conjugated to Keyhole Limpet Haemocyanin.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human Transcription factor AP-2 gamma aa 1-50 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q92754
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
AP2 gamma also known as TFAP2C functions as a transcription factor and belongs to the AP-2 family. AP2 gamma has a molecular weight of approximately 50 kDa. It regulates gene expression by binding to DNA sequence-specific sites influencing diverse cellular processes. This protein commonly expresses in tissues like mammary glands and is important in embryonic development. TFAP2C plays a role in differentiation and development across different cell types.
- Biological function summary
AP2 gamma acts as a significant regulator of gene networks that control cell growth and differentiation. This protein contributes to transcriptional activation and repression often functioning within multiprotein complexes. It regulates the expression of genes involved in epithelial cell differentiation and morphogenesis. Importantly TFAP2C helps in the development of ectodermal tissues supporting cellular behaviors necessary for proper tissue formation.
- Pathways
TFAP2C is involved in pathways that include developmental processes and differentiation. In particular it takes part in the Wnt signaling pathway influencing gene expression patterns that govern development. AP2 gamma interacts with proteins such as beta-catenin within the Wnt pathway modulating cell fate and proliferation. Another important pathway is the estrogen receptor signaling pathway where TFAP2C partners with proteins like ERα to regulate hormone-responsive genes.
- Associated diseases and disorders
AP2 gamma has links to breast cancer and neural tube defects. In breast cancer TFAP2C modulates genes associated with cancer progression and treatment response interacting with proteins like HER2. Mutations or dysregulation of TFAP2C can also lead to developmental anomalies like neural tube defects possibly due to altered gene expression during embryonic development. Understanding these connections provides insight into therapeutic strategies and developmental biology.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AP2 gamma/TFAP2C antibody (ab203691)
Immunohistochemical analysis of formalin-fixed and paraffin embedded mouse embryo labeling AP2 gamma/TFAP2C with ab203691 at 1/200 followed by conjugation to the secondary antibody and DAB staining.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AP2 gamma/TFAP2C antibody (ab203691)
Immunohistochemical analysis of formalin-fixed and paraffin embedded rat brain labeling AP2 gamma/TFAP2C with ab203691 at 1/200 followed by conjugation to the secondary antibody and DAB staining.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com