Rabbit Polyclonal APC antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human APC.
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- Nature communications 12:26782021Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarija Kojic,Tomasz Gawda,Monika Gaik,Alexander Begg,Anna Salerno-Kochan,Nyoman D Kurniawan,Alun Jones,Katarzyna Drożdżyk,Anna Kościelniak,Andrzej Chramiec-Głąbik,Soroor Hediyeh-Zadeh,Maria Kasherman,Woo Jun Shim,Enakshi Sinniah,Laura A Genovesi,Rannvá K Abrahamsen,Christina D Fenger,Camilla G Madsen,Julie S Cohen,Ali Fatemi,Zornitza Stark,Sebastian Lunke,Joy Lee,Jonas K Hansen,Martin F Boxill,Boris Keren,Isabelle Marey,Margarita S Saenz,Kathleen Brown,Suzanne A Alexander,Sergey Mureev,Alina Batzilla,Melissa J Davis,Michael Piper,Mikael Bodén,Thomas H J Burne,Nathan J Palpant,Rikke S Møller,Sebastian Glatt,Brandon J WainwrightPubMed 33976153
- Aging 12:23808-238212020Effect of Klotho protein during porcine oocyte maturation via Wnt signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEui Hyun Kim et. al.PubMed 33176278
- Theranostics 10:74-902020Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLin-Yuan Zhang et. al.PubMed 31903107
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7 - 8
Preservative: 0.09% Sodium azide
Constituents: 1.815% Tris, 1.764% Sodium citrate, 0.021% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human APC. The exact immunogen used to generate this antibody is proprietary information. Database link P25054
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Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
| Chicken | Predicted |
| Chimpanzee | Predicted |
| Cow | Predicted |
| Dog | Predicted |
| Gorilla | Predicted |
| Guinea pig | Predicted |
| Horse | Predicted |
| Pig | Predicted |
| Platypus | Predicted |
| Rabbit | Predicted |
| Rhesus monkey | Predicted |
| Xenopus tropicalis | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500 - 1/2000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Xenopus tropicalis, Platypus, Gorilla | Dilution info - | Notes - |
Associated Products
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Target data
Function
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Alternative names
DP2.5, APC, Adenomatous polyposis coli protein, Protein APC, Deleted in polyposis 2.5
Recommended products
Rabbit Polyclonal APC antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human APC.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7 - 8
Preservative: 0.09% Sodium azide
Constituents: 1.815% Tris, 1.764% Sodium citrate, 0.021% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human APC. The exact immunogen used to generate this antibody is proprietary information. Database link P25054
- Purification technique
- Affinity purification Immunogen
- Concentration
- Purification notes
ab72040 was affinity purified using an epitope specific to APC immobilized on solid support.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APC antibody (ab72040)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling APC with ab72040 at 1/1000 (1µg/ml). Detection: DAB.
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