JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB93518

APC Anti-CCR7 antibody [4B12]

Be the first to review this product! Submit a review

|

(1 Publication)

Rat Monoclonal CCR7 antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing Ccr7 protein.

View Alternative Names

CD197, CMKBR7, EBI1, EVI1, CCR7, C-C chemokine receptor type 7, C-C CKR-7, CC-CKR-7, CCR-7, BLR2, CDw197, Epstein-Barr virus-induced G-protein coupled receptor 1, MIP-3 beta receptor, EBV-induced G-protein coupled receptor 1

1 Images
Flow Cytometry - APC Anti-CCR7 antibody [4B12] (AB93518)
  • Flow Cyt

Unknown

Flow Cytometry - APC Anti-CCR7 antibody [4B12] (AB93518)

Staining of C57Bl/6 splenocytes with FITC anti-mouse CD4 (GK1.5) and either 0.5 µg of ab93518 (right) or 0.5 µg of APC Rat IgG2a Iso Control (left). Cells were stained at 37°C for 0.5 hours and Fc receptor binding was blocked by staining cells with 5 µg/million cells anti-mouse CD16/32. Cells in the lymphocyte gate were used for analysis.

  • 578 PE

    PE Anti-CCR7 antibody [4B12]

  • Carrier free

    Anti-CCR7 antibody [4B12] - Low endotoxin, Azide free

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

4B12

Isotype

IgG2a

Light chain type

kappa

Conjugation

APC

Excitation/Emission

Ex: 650nm, Em: 660nm

Carrier free

No

Reacts with

Mouse

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing Ccr7 protein. The exact immunogen used to generate this antibody is proprietary information.

P47774

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1 µg for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS, 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCR7 also known as CD197 is a chemokine receptor with a molecular mass of approximately 43-48 kDa. The receptor is known to be expressed predominantly in lymphoid tissues such as the spleen and lymph nodes. Additionally CCR7 is found on various immune cells like T cells and dendritic cells. Researchers study CCR7 using different methods such as CCR7-PE and CCR7-APC antibody staining in flow cytometry to examine its expression on immune cells in various conditions.
Biological function summary

CCR7 plays an important role in directing the migration and homeostasis of T cells and dendritic cells. It is not part of a larger protein complex but interacts functionally with specific signaling enzymes upon activation. CCR7 is important for the function of the immune system aiding in the development of adaptive immunity by controlling lymphocyte movement and positioning in lymphoid tissues. This receptor assists in guiding cells to specific lymphoid organs where immune responses are initiated and maintained.

Pathways

CCR7 is significantly involved in the CCL19/CCL21 chemokine signaling pathways which help direct immune cell positioning. CCR7 interacts with these chemokines to regulate the trafficking of cells to lymphoid tissues. Additionally it works in tandem with other receptors like CCR5 in the regulation of immune cell mobilization. These pathways are essential in coordinating the immune response during infection and inflammation.

CCR7 is connected with cancer metastasis and chronic inflammatory diseases. Its role in cell migration makes it relevant in the metastasis of certain cancers where cells misregulate their movement and spread from the original tumor site. Additionally CCR7's involvement in chronic inflammatory diseases highlights its connection to rheumatoid arthritis where it may interact with other proteins such as CCL19 and CCL21 contributing to disease progression. Understanding these interactions helps develop potential therapeutic strategies targeting CCR7 in such diseases.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
See full target information CCR7
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

American journal of physiology. Renal physiology 280:F343-55 PubMed11208610

2001

Mechanisms underlying renoprotection during renin-angiotensin system blockade.

Applications

Unspecified application

Species

Unspecified reactive species

M W Taal,G M Chertow,H G Rennke,A Gurnani,T Jiang,A Shahsafaei,J L Troy,B M Brenner,H S Mackenzie
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB32075

Anti-CCR7 antibody [E75]

20ul selling size|RabMAb|Recombinant

ELISA - Anti-CCR7 antibody [E75] (AB32075)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB277275

Alexa Fluor® 488 Anti-CD4 antibody [EPR19514]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 488 Anti-CD4 antibody [EPR19514] (AB277275)

  • 1
  • 1
Primary Antibodies

AB200317

Alexa Fluor® 647 Anti-CD45 antibody [EP322Y]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Alexa Fluor® 647 Anti-CD45 antibody [EP322Y] (AB200317)

  • 0
  • 0
Primary Antibodies

AB313397

Alexa Fluor® 647 Anti-CD69 antibody [EPR21814]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 647 Anti-CD69 antibody [EPR21814] (AB313397)

  • 0
  • 0
Primary Antibodies

AB284640

Alexa Fluor® 488 Anti-CD44 antibody [EPR18668]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 488 Anti-CD44 antibody [EPR18668] (AB284640)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com