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AB272268

APC Anti-CD134 / OX40L receptor antibody [OX-86]

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Rat Monoclonal CD134 / OX40L receptor antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Mouse samples.

View Alternative Names

CD134, Ox40, Txgp1, Tnfrsf4, Tumor necrosis factor receptor superfamily member 4, OX40 antigen, OX40L receptor

1 Images
Flow Cytometry - APC Anti-CD134 / OX40L receptor antibody [OX-86] (AB272268)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-CD134 / OX40L receptor antibody [OX-86] (AB272268)

C57Bl/6 splenocytes were stimulated for 3 days with ConA and then stained with FITC Anti-Mouse CD3 and 0.125 ug ab272268 (right panel) or 0.125 ug APC Rat IgG1 (left panel).

  • 695 PerCP/Cy5.5®

    PerCP/Cy5.5® Anti-CD134 / OX40L receptor antibody [OX-86]

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

OX-86

Isotype

IgG1

Light chain type

kappa

Conjugation

APC

Excitation/Emission

Ex: 650nm, Em: 660nm

Carrier free

No

Reacts with

Mouse

Applications

Flow Cyt

applications

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Complementary Products

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Primary Antibodies

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PE/Cy7® Anti-CD69 antibody [H1.2F3]

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Primary Antibodies

AB196147

Alexa Fluor® 647 Anti-CD4 antibody [EPR6855]

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Assay Kits

AB231926

Human OX40 ELISA Kit (TNFRSF4)

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Sandwich ELISA - Human OX40 ELISA Kit (TNFRSF4) (AB231926)

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Proteins & Peptides

AB307791

Recombinant Human CD134 / OX40L receptor Protein (His-tag) (Active)

Premium Bioactive

Functional Studies - Recombinant Human CD134 / OX40L receptor Protein (His-tag) (Active) (AB307791)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>Use at 0.125 μg per reaction.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Purification notes
Purified from tissue culture supernatant.
Storage buffer
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: 0.87% Sodium chloride, 0.12% Sodium dihydrogen phosphate, 0.1% Gelatin
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD134 also known as OX40 or TNFRSF4 is a receptor that plays an essential role in immune response regulation. This receptor is part of the tumor necrosis factor receptor (TNFR) superfamily and has a molecular mass of approximately 50 kDa. CD134 is expressed on activated T cells particularly CD4+ T cells and is present on various other immune cells under specific conditions. The receptor binds to the OX40L its ligand which is expressed on antigen-presenting cells such as dendritic cells and B cells.
Biological function summary

CD134 influences T cell proliferation survival and memory formation being an important component of the immune system's adaptive response. OX40L engagement with CD134 enhances the activation and survival of T cells promoting long-term immunity. This interaction does not form part of a larger complex but functions as a direct signaling mechanism that augments T cell receptor (TCR) signaling leading to increased cytokine production and sustained immune responses essential for controlling infections and cancer.

Pathways

CD134 signaling intersects with the nuclear factor-kappa B (NF-κB) and phosphoinositide 3-kinase (PI3K) pathways. These pathways play significant roles in regulating immune responses and cell survival. Through the NF-κB pathway CD134 influences gene transcription related to immune activation. It also connects with other immune regulatory proteins such as CD28 which further potentiates T cell responses and enhances effector functions.

CD134 has connections to autoimmune diseases and cancers. Overactivity of the CD134-OX40L pathway can lead to exacerbated autoimmune conditions such as lupus. This receptor has also been implicated in tumor immunity where its activation enhances the anti-tumor response of T cells. CD134 interacts with CTLA-4 another immune checkpoint protein playing a role in balancing immune activation and regulation within these disease contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity).
See full target information Tnfrsf4
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Product promise

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