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Mouse Monoclonal CD200 / OX2 antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Human, Cynomolgus monkey samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CD200.


Images

Flow Cytometry - APC Anti-CD200 / OX2 antibody [OX104] (AB134489), expandable thumbnail
  • Flow Cytometry - APC Anti-CD200 / OX2 antibody [OX104] (AB134489), expandable thumbnail

Publications

Key facts

Isotype
IgG1
Host species
Mouse
Conjugation
APC
Excitation/Emission
Ex: 650nm, Em: 660nm
Storage buffer

pH: 7.2
Preservative: 0.09% Sodium azide
Constituents: 0.2% BSA, 0.09% PBS

Form
Liquid
Clonality
Monoclonal

Immunogen

  • Recombinant Fragment Protein within Human CD200. The exact immunogen used to generate this antibody is proprietary information. Database link P41217

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
Flow Cyt
Human
Tested
Cynomolgus monkey
Tested

Tested
Tested

Species
Human
Dilution info
5 µL for 106 Cells
Notes

ab37391 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Species
Cynomolgus monkey
Dilution info
5 µL for 106 Cells
Notes

ab37391 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Associated Products

Select an associated product type

12 products for Alternative Product

Target data

Function

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

Alternative names

CD200, MOX1, MOX2, My033, OX-2 membrane glycoprotein

Recommended products

Mouse Monoclonal CD200 / OX2 antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Human, Cynomolgus monkey samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CD200.

Key facts

Isotype
IgG1
Conjugation
APC
Excitation/Emission
Ex: 650nm, Em: 660nm
Form
Liquid
Clonality
Monoclonal
Immunogen
  • Recombinant Fragment Protein within Human CD200. The exact immunogen used to generate this antibody is proprietary information. Database link P41217
Clone number
OX104
Purification technique
Affinity purification Protein G
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

CD200 also known as OX2 is a cell surface glycoprotein with a molecular mass of approximately 43 kDa. It plays a mechanical role in immune response regulation. CD200 expression occurs on several cell types such as thymocytes neurons vascular endothelium and splenocytes including cynomolgus monkey splenocytes. This protein generally modulates interactions between cells sending inhibitory signals through its receptor CD200R found on myeloid cells and certain lymphoid cells.

Biological function summary

CD200 regulates the immune system by inhibiting inflammatory responses and maintaining immune homeostasis. It does not act as part of a significant multi-protein complex but directly interacts with CD200R. This interaction promotes an anti-inflammatory state and is important in preventing autoimmune diseases and excessive tissue damage. The expression of CD200 is also an indicator of immune tolerance in various tissues.

Pathways

CD200 is involved in immune regulatory pathways. It plays a pivotal role in the suppression of immune responses through the CD200-CD200R signaling pathway. This pathway is vital for dampening inflammatory processes related to autoimmune reactions and is consequently linked to the maintenance of tissue homeostasis. Proteins related to CD200 through these pathways include CD200R and other molecules involved in immune checkpoint pathways.

Associated diseases and disorders

CD200 expression correlates with several conditions including cancer and autoimmune diseases. The overexpression of CD200 in certain tumors promotes immune evasion thereby favoring tumor progression. Conversely reduced CD200 levels are associated with autoimmune disorders where a hyperactive immune system attacks self-tissues. Through these disease contexts CD200 operates alongside proteins such as CD200R and OX90 impacting disease progression and immune system modulation.

Product promise

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2 product images

  • Flow Cytometry - APC Anti-CD200 / OX2 antibody [OX104] (ab134489), expandable thumbnail
    This image is courtesy of an anonymous customer review

    Flow Cytometry - APC Anti-CD200 / OX2 antibody [OX104] (ab134489)

    Flow cytometry analysis of Cynomolgus monkey whole blood after red blod cell lysis, staining CD200 / OX2 with ab134489. Cells were fixed with paraformaldehyde. The sample was incubated with the primary antibody (1/100 in 1% BSA in PBS) for 1 hour at 4°C. .

    Gating Strategy: Live lymphocytes

  • Flow Cytometry - APC Anti-CD200 / OX2 antibody [OX104] (ab134489), expandable thumbnail

    Flow Cytometry - APC Anti-CD200 / OX2 antibody [OX104] (ab134489)

    Flow cytometry analysis of normal Human peripheral blood cells with Anti-Human CD19 PE and 0.25 µg of Mouse IgG1 kappa Isotype Control APC (left) or 5 µl (0.25 µg) ab134489 (right). Cells in the lymphocyte gate were used for analysis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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