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Mouse Monoclonal CD24 antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Human samples.

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Images

Flow Cytometry - APC Anti-CD24 antibody [SN3] (AB239286), expandable thumbnail

Key facts

Isotype
IgG1
Host species
Mouse
Conjugation
APC
Excitation/Emission
Ex: 650nm, Em: 660nm
Storage buffer

pH: 7.4
Preservative: 0.0975% Sodium azide
Constituents: PBS

Form
Liquid
Clonality
Monoclonal

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
Flow Cyt
Human
Tested

Tested
Tested

Species
Human
Dilution info
10 µL for 106 Cells
Notes

(or 100 μl of whole blood).

Associated Products

Select an associated product type

6 products for Alternative Version

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Target data

Function

May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).

Alternative names

CD24, CD24A, Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen

Recommended products

Mouse Monoclonal CD24 antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Human samples.

Key facts

Isotype
IgG1
Conjugation
APC
Excitation/Emission
Ex: 650nm, Em: 660nm
Form
Liquid
Clonality
Monoclonal
Clone number
SN3
Purification technique
Size-exclusion chromatography
Concentration
Loading...
Purification notes

Purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

CD24 also known as heat-stable antigen or CD24A is a glycosylphosphatidylinositol (GPI)-anchored membrane protein with a molecular mass of approximately 30-50 kDa. It is expressed on the surface of many cell types including B cells T cells neutrophils and epithelial cells. CD24 plays a role in cell adhesion and signaling processes impacting immune response and cancer progression. Its expression is often used as a marker in identification and classification procedures such as flow cytometry.

Biological function summary

CD24 functions like a molecular "switch" modulating signals sent between cells. It acts as a ligand for multiple receptors and participates in cellular communication especially influencing the immune system. Part of its biological role involves interaction within cellular complexes impacting immune modulation and inflammatory responses. CD24's location at the interface of cellular microenvironments makes it critical for cellular response adaptation to varied external stimuli.

Pathways

CD24 participates in both immune signaling and cancer-related pathways. It plays a significant role in the suppression of the immune response often interacting with proteins like Siglec-10 in these pathways. CD24's involvement in these pathways contributes to cell survival and proliferation particularly within cancer development. The protein’s interaction within specified signaling pathways allows it to influence downstream targets that regulate gene expression and cellular functions.

Associated diseases and disorders

CD24 has significant connections to cancer and inflammatory diseases. It is highly expressed in various cancers including breast and prostate cancer where it correlates with poor prognosis due to its role in apoptosis evasion and metastasis. CD24 interacts with proteins like HMGB1 and is implicated in inflammatory conditions where it modulates immune cell activity. Extensive research into CD24's involvement in these disorders may lead to targeted therapies including the development of anti-CD24 antibodies for therapeutic interventions.

Product promise

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1 product image

  • Flow Cytometry - APC Anti-CD24 antibody [SN3] (ab239286), expandable thumbnail

    Flow Cytometry - APC Anti-CD24 antibody [SN3] (ab239286)

    Flow cytometric analysis of human peripheral blood cells labeling CD24 with ab239286. Surface staining. Gated on leukocytes.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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