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BiochemicalsProteins and Peptides
Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Mouse Monoclonal CD3d antibody - conjugated to APC. Suitable for Flow Cyt, Flow Cyt (Intra) and reacts with Human samples. Immunogen corresponding to Cell preparation containing CD3D protein.
IgG1
Mouse
APC
Ex: 650nm, Em: 660nm
pH: 7.4
Preservative: 0.0975% Sodium azide
Constituents: PBS
Liquid
Monoclonal
Flow Cyt | Flow Cyt (Intra) | |
---|---|---|
Human | Tested | Expected |
Primates | Predicted | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 10 µL for 106 Cells | Notes (or 100 μl of whole blood). |
Species | Dilution info | Notes |
---|---|---|
Species Primates | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 10 µL for 106 Cells | Notes (or 100 μl of whole blood). |
Species | Dilution info | Notes |
---|---|---|
Species Primates | Dilution info - | Notes - |
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells(PubMed:12215456).
T-cell surface glycoprotein CD3 delta chain, T-cell receptor T3 delta chain, CD3D, T3D
Mouse Monoclonal CD3d antibody - conjugated to APC. Suitable for Flow Cyt, Flow Cyt (Intra) and reacts with Human samples. Immunogen corresponding to Cell preparation containing CD3D protein.
T-cell surface glycoprotein CD3 delta chain, T-cell receptor T3 delta chain, CD3D, T3D
IgG1
Mouse
APC
Ex: 650nm, Em: 660nm
pH: 7.4
Preservative: 0.0975% Sodium azide
Constituents: PBS
Liquid
Monoclonal
UCHT1
Size-exclusion chromatography
ab239287 reacts with the epsilon chain of the CD3 complex.
Purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
Blue Ice
+4°C
Store in the dark
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Flow cytometric analysis of human peripheral blood labeling CD3 with ab239287. Surface staining. Gated on leukocytes.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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