AB95725

APC Anti-CD41 antibody [MWReg30]

Name: APC Anti-CD41 antibody [MWReg30] (ab95725) | Abcam
Brand: Abcam Limited
SKU: AB95725
Price: 260 USD
Availability: InStock

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(5 Publications )

Anti-CD41 antibody [MWReg30] conjugated to APC - suitable for flow cytometry, and reacts with mouse samples. Clone [MWReg30] is a rat monoclonal antibody and one of the most commonly used clones for flow cytometry.

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1 Images

Flow Cytometry - APC Anti-CD41 antibody [MWReg30] (AB95725)

Flow Cyt

Unknown

Flow Cytometry - APC Anti-CD41 antibody [MWReg30] (AB95725)

Staining of mouse platelets with anti-Mouse CD61 PE and 0.125µg of Rat IgG1 kappa Isotype Control APC (left) or 0.125 µg of ab95725 (right).

Biotin

Biotin Anti-CD41 antibody [MWReg30]
578 PE

PE Anti-CD41 antibody [MWReg30]
778 PE/Cy7®

PE/Cy7® Anti-CD41 antibody [MWReg30]

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

MWReg30

Isotype

IgG1

Light chain type

kappa

Conjugation

APC

Excitation/Emission

Ex: 650nm, Em: 660nm

Carrier free

Reacts with

Mouse

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing Itga2b protein. The exact immunogen used to generate this antibody is proprietary information.

Q9QUM0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "0.125-0.25 µg for 10^5-10^8 Cells", "FlowCyt-species-notes": "<p>A final volume of 100μl is recommended.</p><p><a href='/en-us/products/unavailable/rat-igg1-kappa-monoclonal-klhg1-2-2-apc-isotype-control-ab154433'>ab154433</a> - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

pH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS, 0.1% Gelatin

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Integrin alpha-IIb/beta-3 (ITGA2B : ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (By similarity). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface (By similarity). Integrin ITGA2B : ITGB3 is also the receptor of erythrocyte-specific ICAM4 ligand involved in heterotypic cell-cell adhesion between erythrocytes and activated platelets (By similarity).

See full target information Itga2b

Alternative Names

CD41, Integrin alpha-IIb, GPalpha IIb, Platelet membrane glycoprotein IIb, GPIIb, Itga2b

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Theranostics 11:9791-9804 PubMed34815786

2021

CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Chaojun Tang,Lei Wang,Yulan Sheng,Zhong Zheng,Zhanli Xie,Fan Wu,Tao You,Lijie Ren,Lijun Xia,Changgeng Ruan,Li Zhu

Proceedings of the National Academy of Sciences of the United States of America 102:134-9 PubMed15623562

2004

Characterization of purified intraembryonic hematopoietic stem cells as a tool to define their site of origin.

Applications

Flow Cyt

Species

Unspecified reactive species

Julien Y Bertrand,Sébastien Giroux,Rachel Golub,Michèle Klaine,Abdelali Jalil,Laurent Boucontet,Isabelle Godin,Ana Cumano

Development (Cambridge, England) 129:2003-13 PubMed11934866

2002

Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells.

Applications

Flow Cyt

Species

Unspecified reactive species

Maria Teresa Mitjavila-Garcia,Michel Cailleret,Isabelle Godin,Maria Manuela Nogueira,Karine Cohen-Solal,Valérie Schiavon,Yann Lecluse,Françoise Le Pesteur,Anne Hélène Lagrue,William Vainchenker

Blood 98:1095-9 PubMed11493456

2001

Therapeutic efficacy of intravenous immunoglobulin preparations depends on the immunoglobulin G dimers: studies in experimental immune thrombocytopenia.

Applications

Unspecified application

Species

Unspecified reactive species

J L Teeling,T Jansen-Hendriks,T W Kuijpers,M de Haas,J G van de Winkel,C E Hack,W K Bleeker

Blood 94:684-93 PubMed10397735

1999

Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice.

Applications

Flow Cyt

Species

Unspecified reactive species

B Nieswandt,B Echtenacher,F P Wachs,J Schröder,J E Gessner,R E Schmidt,G E Grau,D N Männel

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

APC Anti-CD41 antibody [MWReg30]

Flow Cytometry - APC Anti-CD41 antibody [MWReg30] (AB95725)

Related conjugates and formulations (3)

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Conjugation

Excitation/Emission

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Product protocols

Target data

Alternative Names

Publications (5)

Product promise