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AB303066

APC Anti-Claudin 1 antibody [EPRR18871]

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Rabbit Recombinant Monoclonal Claudin 1 antibody - conjugated to APC.

View Alternative Names

CLD1, SEMP1, UNQ481/PRO944, CLDN1, Claudin-1, Senescence-associated epithelial membrane protein

  • Unconjugated

    Anti-Claudin 1 antibody [EPRR18871]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-Claudin 1 antibody [EPRR18871]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-Claudin 1 antibody [EPRR18871]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-Claudin 1 antibody [EPRR18871]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-Claudin 1 antibody [EPRR18871]

  • Carrier free

    Anti-Claudin 1 antibody [EPRR18871] - BSA and Azide free

  • 578 PE

    PE Anti-Claudin 1 antibody [EPRR18871]

  • HRP

    HRP Anti-Claudin 1 antibody [EPRR18871]

  • Carrier free

    Anti-Claudin 1 antibody [RM1186] - BSA and Azide free

  • Unconjugated

    Anti-Claudin 1 antibody [RM1186]

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPRR18871

Isotype

IgG

Conjugation

APC

Excitation/Emission

Ex: 650nm, Em: 660nm

Carrier free

No

Applications

Antibody Labelling, Target Binding Affinity

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 98% PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Claudin 1 also known as CLDN1 is a protein that plays a fundamental role in the formation of tight junctions in the epithelial cells. This claudin protein has a molecular weight of approximately 22 kDa. You can find it expressed in various tissues including the skin liver kidney and lungs. Claudin 1 belongs to the claudin family which consists of transmembrane proteins involved in sealing the space between adjacent cells therefore ensuring tissue integrity.
Biological function summary

This claudin protein contributes to establishing and maintaining the barrier function that controls paracellular transport which is the movement of substances between cells. Claudin 1 participates as a critical component of the tight junction complex and it interacts with other proteins such as occludin and zonula occludens. These interactions contribute to the regulation and maintenance of cell polarity and signaling.

Pathways

Claudin 1 is involved in the epithelial cell signaling pathways that influence cellular proliferation and differentiation. One significant pathway is the Wnt signaling pathway where claudin 1 cooperates with other claudins and proteins like β-catenin to regulate gene transcription. Additionally it is implicated in the MAPK pathway which involves signaling cascades that affect cell growth division and response to external stress.

Claudin 1 shows a strong association with cancers particularly hepatocellular carcinoma and melanoma. In these conditions changes in claudin 1 expression levels can affect tumor progression and metastasis. It also associates with other proteins like E-cadherin impacting cell adhesion and epithelial-mesenchymal transition in cancerous cells. Moreover abnormalities in claudin 1 expression relate to skin disorders such as ichthyosis which is marked by a dysfunction in the skin barrier.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed : 23407391).. (Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes (PubMed : 17325668, PubMed : 20375010, PubMed : 24038151). Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell (PubMed : 20375010). Acts as a receptor for dengue virus (PubMed : 24074594).
See full target information CLDN1
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Product promise

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