AB233298

APC/Cy7® Anti-CD4 antibody [MEM-241]

Name: Anti-CD4 APC/Cy7® antibody [MEM241] (ab233298) IgG1 | Abcam
Brand: Abcam Limited
SKU: AB233298
Price: 475 USD
Availability: InStock

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(2 Publications)

Mouse Monoclonal CD4 antibody - conjugated to APC/Cy7®. Suitable for Flow Cyt and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CD4.

View Alternative Names

CD4, T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3

3 Images

Flow Cytometry - APC/Cy7® Anti-CD4 antibody [MEM-241] (AB233298)

Flow Cyt

Supplier Data

Flow Cytometry - APC/Cy7® Anti-CD4 antibody [MEM-241] (AB233298)

Flow cytometric analysis of surface stained human peripheral blood cells, labeling CD4 with ab233298. Leukocyte gate.

Flow Cyt

Supplier Data

Flow Cytometry - APC/Cy7® Anti-CD4 antibody [MEM-241] (AB233298)

Flow cytometry surface staining pattern of human peripheral whole blood stained using ab233298 (concentration in sample 0.33 µg/ml).

Flow Cyt

Supplier Data

Flow Cytometry - APC/Cy7® Anti-CD4 antibody [MEM-241] (AB233298)

Flow cytometry surface staining pattern of human peripheral whole blood stained using ab233298 (concentration in sample 0.33 µg/ml).

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MEM-241

Isotype

IgG1

Light chain type

kappa

Conjugation

APC/Cy7®

Excitation/Emission

Ex: 650nm, Em: 785nm

Carrier free

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Recombinant Fragment Protein within Human CD4. The exact immunogen used to generate this antibody is proprietary information.

P01730

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "4 µL for 10^6 Cells", "FlowCyt-species-notes": "<p>(or 100 μL whole blood)</p>" } } }

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Product details

This product or portions thereof is manufactured under license from Carnegie Mellon University under U.S. Patent Number 5, 268, 486 and related patents. Cy® and CyDye® are trademarks of Cytiva.

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Properties and storage information

Form

Liquid

Purification technique

Size-exclusion chromatography

Purification notes

The purified antibody is conjugated with tandem dye APC-Cy™7 under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

Storage buffer

pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

Store in the dark

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule : peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.. (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed : 12089508, PubMed : 16331979, PubMed : 2214026, PubMed : 9641677). Down-regulated by HIV-1 Vpu (PubMed : 17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed : 7909607).

See full target information CD4

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

PloS one 19:e0310389 PubMed39292698

2024

Visfatin (NAMPT) expression in human placenta cells in normal and pathological conditions and its hormonal regulation in trophoblast JEG-3 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Monika Dawid,Patrycja Kurowska,Piotr Pawlicki,Małgorzata Kotula-Balak,Tomasz Milewicz,Joelle Dupont,Agnieszka Rak

Immunity, inflammation and disease 10:e723 PubMed36301026

2022

Low serum level of 25-OH vitamin D relates to Th17 and treg changes in colorectal cancer patients.

Applications

Unspecified application

Species

Unspecified reactive species

Bai Chen,Liugen Jin

View all publications

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