Rabbit Recombinant Monoclonal EDG3/S1P3 antibody - conjugated to APC.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
C9orf108, C9orf47, EDG3, S1PR3, Sphingosine 1-phosphate receptor 3, S1P receptor 3, S1P3, Endothelial differentiation G-protein coupled receptor 3, Sphingosine 1-phosphate receptor Edg-3, S1P receptor Edg-3
Rabbit Recombinant Monoclonal EDG3/S1P3 antibody - conjugated to APC.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
EDG3 also known as S1P3 is a G protein-coupled receptor with a molecular mass of approximately 43 kDa. It interacts with sphingosine-1-phosphate (S1P) a bioactive lipid molecule involved in diverse cellular processes. EDG3/S1P3 is expressed in various tissues such as the cardiovascular system lungs and lymphoid organs highlighting its importance in different physiological contexts. As a member of the S1P receptor family it plays a significant role in cellular communication.
EDG3/S1P3 affects several critical processes such as cell proliferation survival and migration. It functions within complexes that modulate intracellular signaling pathways. The receptor is involved in the regulation of immune responses and vascular stability by mediating signals that maintain endothelial barrier function and lymphocyte trafficking. Its interactions with other S1P receptors also contribute to its broad influence on cellular functions.
EDG3/S1P3 participates in the sphingolipid signaling pathways and the PI3K-Akt pathway. These pathways are integral to cell growth and survival influencing various physiological responses. The receptor shares functional relationships with proteins such as EDG1/S1P1 and EDG5/S1P2 which also bind S1P and are involved in similar signaling cascades. These interactions align EDG3/S1P3 with essential cellular processes emphasizing its role in maintaining homeostasis.
EDG3/S1P3 has associations with cardiovascular diseases and cancer. Its role in endothelial barrier function ties it to cardiovascular health where dysregulation can lead to conditions such as atherosclerosis. In cancer abnormal EDG3/S1P3 signaling can contribute to tumor growth and metastasis by influencing cell migration and survival. The receptor's involvement in these diseases links it to other proteins like VEGF which are essential in angiogenesis and vascular maintenance highlighting its therapeutic potential.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com