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AB270639

APC Anti-IL2 Receptor beta/p75 antibody [TU27]

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Mouse Monoclonal IL2 Receptor beta/p75 antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Cell preparation containing IL2RB protein.

View Alternative Names

CD122, IL15RB, IL2RB, Interleukin-2 receptor subunit beta, IL-2 receptor subunit beta, IL-2R subunit beta, IL-2RB, High affinity IL-2 receptor subunit beta, Interleukin-15 receptor subunit beta, p70-75, p75

3 Images
Flow Cytometry - APC Anti-IL2 Receptor beta/p75 antibody [TU27] (AB270639)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-IL2 Receptor beta/p75 antibody [TU27] (AB270639)

Flow cytometry analysis of IL2 Receptor beta/p75 positive (CD122) NK cells (red) and neutrophil granulocytes (black) cells labeling IL2 Receptor beta/p75 using ab270639. Concentration of 10 μl reagent/100μl peripheral whole blood. Surface staining.

Flow Cytometry - APC Anti-IL2 Receptor beta/p75 antibody [TU27] (AB270639)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-IL2 Receptor beta/p75 antibody [TU27] (AB270639)

Flow cytometric analysis of human peripheral whole blood cells labeling IL2 Receptor beta/p75 using ab270639. The concentration of 10 μl reagent/ 100μl of peripheral whole blood.

Flow Cytometry - APC Anti-IL2 Receptor beta/p75 antibody [TU27] (AB270639)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-IL2 Receptor beta/p75 antibody [TU27] (AB270639)

Flow cytometric analysis of human peripheral whole blood cells labeling IL2 Receptor beta/p75 using ab270639. The concentration of 10 μl reagent/ 100μl of peripheral whole blood.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

TU27

Isotype

IgG1

Light chain type

kappa

Conjugation

APC

Excitation/Emission

Ex: 650nm, Em: 660nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing IL2RB protein. The exact immunogen used to generate this antibody is proprietary information.

P14784

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Size-exclusion chromatography
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The IL2 Receptor beta also known as IL-2R beta IL2R beta or CD122/IL2RB protein is a component of the interleukin-2 receptor complex. It is part of the receptor system for the cytokine IL-2. This receptor subunit has a molecular mass of approximately 75 kDa and gets alternatively referred to as IL2R beta or p75. It is expressed on the surface of activated T cells natural killer (NK) cells and in some cases myeloid lineage cells. This expression pattern correlates IL2R beta's role in essential immune functions and signaling processes.
Biological function summary

IL2R beta plays a critical role in cytokine binding and signal transduction for the interleukin-2 receptor which is a heterodimeric complex. This complex consists of the IL-2 receptor alpha (CD25) IL-2 receptor beta and a common gamma chain (γc CD132). The presence of IL-2R beta allows the receptor to mediate biological processes like cell proliferation differentiation and survival particularly within the immune system. The extent to how IL2R beta integrates into these processes makes it an important player in immune regulation and homeostasis.

Pathways

IL2R beta serves essential functions in the JAK-STAT and PI3K-AKT pathways. The binding of IL-2 to its receptor initiates a cascade of intracellular events which involve Janus kinases (JAKs) and signal transducer and activator of transcription (STATs) leading to transcriptional activation of various genes. Along with these pathways IL2R beta also interacts collaboratively with the gamma chain (γc) in promoting Downstream signaling events which enhance cell proliferation and survival.

IL2R beta's function has implications in autoimmune diseases and certain types of leukemia. Alterations or dysregulation in IL-2R signaling pathways often play a role in autoimmune conditions due to its importance in maintaining immune tolerance. Moreover given IL-2 receptor's role in T-cell and NK-cell activity aberrations may contribute to uncontrolled cellular proliferation seen in leukemia. Understanding its interplay with the common gamma chain (CD132) can provide insights into therapeutic interventions targeting these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed : 15123770, PubMed : 31040185).
See full target information IL2RB
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Product promise

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