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AB278638

APC Anti-JAK1 (phospho Y1034 + Y1035) antibody [Jak1Y10221023-F11]

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Rabbit Recombinant Monoclonal JAK1 phospho Y1034 + Y1035 antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human JAK1 phospho Y1034 + Y1035.

View Alternative Names

JAK1A, JAK1B, JAK1, Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1

1 Images
Flow Cytometry - APC Anti-JAK1 (phospho Y1034 + Y1035) antibody [Jak1Y10221023-F11] (AB278638)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-JAK1 (phospho Y1034 + Y1035) antibody [Jak1Y10221023-F11] (AB278638)

Flow cytometric analysis of Jurkat cells untreated (red) or treated with IFNα + IL-4 + pervanadate (green) using ab278638, or concentration-matched Rabbit (G9) mAb IgG Isotype Control (FITC Conjugate) for cells untreated (black) or treated with IFNα + IL-4 + pervanadate (blue).

  • Unconjugated

    Anti-JAK1 (phospho Y1034 + Y1035) antibody [Jak1Y10221023-F11]

  • 519 FITC

    FITC Anti-JAK1 (phospho Y1034 + Y1035) antibody [Jak1Y10221023-F11]

  • 578 PE

    PE Anti-JAK1 (phospho Y1034 + Y1035) antibody [Jak1Y10221023-F11]

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

Jak1Y10221023-F11

Isotype

IgG

Light chain type

kappa

Conjugation

APC

Excitation/Emission

Ex: 650nm, Em: 660nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Synthetic Peptide within Human JAK1 phospho Y1034 + Y1035. The exact immunogen used to generate this antibody is proprietary information.

P23458

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "5 µL for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" } } }
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Product details

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Storage buffer
Preservative: 0.09% Sodium azide Constituents: 99.71% PBS, 0.2% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

JAK1 also known as Janus Kinase 1 plays an essential role in transmitting signals within cells. It is a tyrosine kinase enzyme with a molecular weight of approximately 130 kDa. JAK1 is expressed broadly in various tissues and is involved in cytokine receptor signaling. The kinase activity of JAK1 gets activated upon cytokine binding to its respective receptor which leads to phosphorylation events and downstream signaling cascades.
Biological function summary

This enzyme participates significantly in the immune response and hematopoiesis by being part of the JAK-STAT signaling pathway complex. When activated JAK1 phosphorylates specific tyrosine residues on the receptor creating docking sites for STAT proteins which then get phosphorylated by JAK1. This phosphorylation allows STAT proteins to dimerize and translocate to the nucleus affecting gene expression involved in growth survival and differentiation processes.

Pathways

JAK1 is importantly engaged in the JAK-STAT pathway and the Interferon signaling pathway. Within these pathways JAK1 collaborates closely with other proteins like JAK2 TYK2 and STAT proteins. It acts as a mediator of the cellular response to a variety of cytokines and growth factors playing a role in the regulation of immune responses and cell proliferation.

Dysregulation of JAK1 associates with autoimmune diseases like rheumatoid arthritis and certain cancers. JAK1 inhibitors have been developed as therapeutic agents for these conditions targeting its kinase activity to modulate aberrant signaling. The interaction between JAK1 and other kinases such as JAK2 and transcription factors like STATs highlights its importance in disease mechanisms providing a target for drugs to manage inflammatory and malignant disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed : 16239216, PubMed : 28111307, PubMed : 32750333, PubMed : 7615558, PubMed : 8232552). Kinase partner for the interleukin (IL)-2 receptor (PubMed : 11909529) as well as interleukin (IL)-10 receptor (PubMed : 12133952). Kinase partner for the type I interferon receptor IFNAR2 (PubMed : 16239216, PubMed : 28111307, PubMed : 32750333, PubMed : 7615558, PubMed : 8232552). In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins (PubMed : 7759950). Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed : 16239216, PubMed : 32750333, PubMed : 8232552).
See full target information JAK1 phospho Y1034 + Y1035
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Version
Primary Antibodies

AB278782

FITC Anti-JAK1 (phospho Y1034 + Y1035) antibody [Jak1Y10221023-F11]

primary-antibodies

fitc-jak1-phospho-y1034-y1035-antibody-jak1y10221023-f11-ab278782

0

(0 reviews)

Alternative Version
Primary Antibodies

AB278637

PE Anti-JAK1 (phospho Y1034 + Y1035) antibody [Jak1Y10221023-F11]

primary-antibodies

pe-jak1-phospho-y1034-y1035-antibody-jak1y10221023-f11-ab278637

0

(0 reviews)

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