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AB205500

APC Anti-NCAM1 antibody [LT56]

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(1 Publication)

Mouse Monoclonal NCAM1 antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing NCAM1 protein.

View Alternative Names

CD56, NCAM, NCAM1, Neural cell adhesion molecule 1, N-CAM-1, NCAM-1

4 Images
Flow Cytometry - APC Anti-NCAM1 antibody [LT56] (AB205500)
  • Flow Cyt

Unknown

Flow Cytometry - APC Anti-NCAM1 antibody [LT56] (AB205500)

Flow Cytometry analysis of human peripheral blood cells labeling NULL with Anti-NCAM antibody [LT56] (Allophycocyanin) (ab205500).

Flow Cytometry - APC Anti-NCAM1 antibody [LT56] (AB205500)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-NCAM1 antibody [LT56] (AB205500)

Flow cytometry surface staining pattern of human peripheral whole blood stained using ab205500 (concentration in sample 0.11 µg/ml).

Flow Cytometry - APC Anti-NCAM1 antibody [LT56] (AB205500)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-NCAM1 antibody [LT56] (AB205500)

Flow cytometry surface staining pattern of human peripheral whole blood stained using ab205500 (concentration in sample 0.11 µg/ml).

Flow Cytometry - APC Anti-NCAM1 antibody [LT56] (AB205500)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-NCAM1 antibody [LT56] (AB205500)

Flow cytometry surface staining pattern of human peripheral whole blood stained using ab205500 (concentration in sample 0.11 µg/ml).

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

LT56

Isotype

IgG2a

Light chain type

kappa

Conjugation

APC

Excitation/Emission

Ex: 650nm, Em: 660nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing NCAM1 protein. The exact immunogen used to generate this antibody is proprietary information.

P13591

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p>Use 10 μl for 100 μl of Human whole blood or 10<sup><sub>6</sub></sup> cells in suspension.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Size-exclusion chromatography
Storage buffer
pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS, 0.2% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NCAM1 also known as Neural Cell Adhesion Molecule 1 or CD56 is an important cell surface glycoprotein that plays a role in cell-cell adhesion. It has a molecular mass of approximately 120-140 kDa. NCAM1 is widely expressed in various tissues including the nervous system skeletal muscle and certain hematopoietic cells. In flow cytometry and immunohistochemistry NCAM1's expression is extensively studied to track and analyze cell populations using techniques like NCAM1 ELISA for quantification.
Biological function summary

NCAM1 influences neuronal growth survival and synaptic plasticity. This protein is part of the immunoglobulin superfamily and contributes to dynamic interactions during development. NCAM1 exists on cell membranes assisting in the formation and maintenance of tissue structures. In particular cell adhesion molecule CAL53 interacts with NCAM1 highlighting its involvement in synaptic connections. Additionally NCAM1 impacts cellular migration and differentiation particularly in myogenic processes involving MY31's pathway.

Pathways

The NCAM1 protein participates in the MAPK signaling pathway and the PI3K/AKT pathway both essential in cellular growth and survival. NCAM1 acts alongside ERIC1 aiding in the transduction of signals that regulate cytoskeletal rearrangement. These pathways influence cellular communication and responses to external stimuli further enhancing tissue development and regeneration mechanisms.

NCAM1 is associated with neurodegenerative conditions like Alzheimer's disease and certain types of cancer including neuroblastoma. Changes in NCAM1 expression or function can disrupt normal cell adhesion and signaling leading to pathological states. The protein's interaction with cell surface markers such as CD56 mouse marker helps in the diagnosis and therapy of these disorders providing potential therapeutic targets or biomarkers for clinical applications.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.. (Microbial infection) Acts as a receptor for rabies virus.. (Microbial infection) Acts as a receptor for Zika virus.
See full target information NCAM1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 12:3549-3552 PubMed28105088

2016

Clinical significance of lymphocyte subset changes in hemophagocytic lymphohistiocytosis of children.

Applications

Unspecified application

Species

Unspecified reactive species

Qi An,Yi Wang,Shaoyan Hu,Daihua Fang,Chengmin Xuan,Shumei Xu,Mingwei Jin,Qiang Ji
View all publications
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