Mouse Monoclonal Cytokeratin 1 antibody - conjugated to APC. Suitable for Flow Cyt (Intra) and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Cell preparation containing KRT1 protein.
Images
![Flow Cytometry (Intracellular) - APC Anti-pan Cytokeratin antibody [C-11] (AB106166), expandable thumbnail](https://content.abcam.com/products/images/apc-pan-cytokeratin-antibody-c-11-ab106166--flow-cytometry-intracellular-img170871.jpg/_jcr_content/renditions/webp-475.webp "Flow Cytometry (Intracellular) - APC Anti-pan Cytokeratin antibody [C-11] (AB106166)")
![Flow Cytometry (Intracellular) - APC Anti-pan Cytokeratin antibody [C-11] (AB106166), expandable thumbnail](https://content.abcam.com/products/images/apc-pan-cytokeratin-antibody-c-11-ab106166--flow-cytometry-intracellular-img435981.jpg/_jcr_content/renditions/webp-475.webp "Flow Cytometry (Intracellular) - APC Anti-pan Cytokeratin antibody [C-11] (AB106166)")
Publications
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- Mucosal immunology 9:1125-362016Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.
- Endocrinology 155:1453-652014Epithelial and stromal cells of bovine endometrium have roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides in vitro via Toll-like receptors TLR2, TLR1, and TLR6.
- Research communications in molecular pathology and pharmacology 101:115-261998Extraction of cytokeratin from the human submandibular gland and its electrophoretic analysis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesH Hamakawa,T Sumida,H Tanioka,K Sogawa,T YamadaPubMed 9821208
- The Journal of pathology 164:215-241991A series of 14 new monoclonal antibodies to keratins: characterization and value in diagnostic histopathology.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJ Bártek,B Vojtĕsek,Z Stasková,J Bártková,Z Kerekés,A Rejthar,J KovaríkPubMed 1716305
Key facts
- Isotype
IgG1
- Host species
Mouse
- Conjugation
APC
- Excitation/Emission
Ex: 650nm, Em: 660nm
- Storage buffer
pH: 7.4
Preservative: 0.098% Sodium azide
Constituents: 99% PBS, 0.2% BSA- Form
Liquid
- Clonality
Monoclonal
Immunogen
- Cell preparation containing KRT1 protein. The exact immunogen used to generate this antibody is proprietary information. Database link P04264
Reactivity data
Select an application| Flow Cyt (Intra) | |
|---|---|
| Human | Tested |
| Mammals | Predicted |
Flow Cyt (Intra)
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mammals | Dilution info - | Notes - |
Associated Products
Select an associated product type
4 products for Alternative Product
2 products for Alternative Version
Target data
Function
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.
Alternative names
67 kDa cytokeratin, Cytokeratin-1, Hair alpha protein, Keratin-1, Type-II keratin Kb1, CK-1, K1, KRTA, KRT1
Recommended products
Mouse Monoclonal Cytokeratin 1 antibody - conjugated to APC. Suitable for Flow Cyt (Intra) and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Cell preparation containing KRT1 protein.
Key facts
- Isotype
IgG1
- Host species
Mouse
- Conjugation
APC
- Excitation/Emission
Ex: 650nm, Em: 660nm
- Storage buffer
pH: 7.4
Preservative: 0.098% Sodium azide
Constituents: 99% PBS, 0.2% BSA- Form
Liquid
- Clonality
Monoclonal
- Immunogen
- Cell preparation containing KRT1 protein. The exact immunogen used to generate this antibody is proprietary information. Database link P04264
- Clone number
C-11
- Purification technique
Size-exclusion chromatography
- Specificity
ab106166 reacts with Cytokeratin peptides 4, 5, 6, 8, 10, 13, 18.
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
+4°C
- Storage information
Store in the dark
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Pan cytokeratin also known as cytokeratin AE1/AE3 is a cytoskeletal protein complex that consists of different keratin polypeptides. It mechanically supports epithelial cells contributing to their structural integrity. The protein mass is variable due to its composite nature ranging between 40 to 67 kDa. Pan cytokeratin is expressed in epithelial tissues throughout the body serving as a reliable marker for identifying epithelial origin cells in histological studies.
- Biological function summary
Keratins in pan cytokeratin contribute to maintaining structural stability within epithelial cells. They act as components of the cytoskeletal network interacting with other cellular structures to provide protection from stress and mechanical damage. Pan cytokeratin exists as part of the intermediate filament protein complex which plays a significant role in cellular mechanics and cohesion essential for tissue integrity.
- Pathways
Intermediate filaments containing pan cytokeratin participate in pathways related to cell differentiation and stress response. Its interactions with other proteins like desmoplakin and plectin link the cytoskeletal filaments to cell membranes and the extracellular matrix. This involvement is important in pathways related to cellular structural integrity and epithelial-mesenchymal transition (EMT).
- Associated diseases and disorders
Pan cytokeratin serves as a critical marker in the diagnosis of epithelial-derived cancers such as carcinoma and conditions like psoriasis. Abnormal expression patterns of pan cytokeratin indicate tumor presence and origin. Its connection to proteins such as E-cadherin and vimentin assists in understanding the progression and metastasis of cancer by facilitating EMT and tissue invasion diagnostics.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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2 product images
![Flow Cytometry (Intracellular) - APC Anti-pan Cytokeratin antibody [C-11] (ab106166), expandable thumbnail](https://content.abcam.com/products/images/apc-pan-cytokeratin-antibody-c-11-ab106166--flow-cytometry-intracellular-img170871.jpg "Flow Cytometry (Intracellular) - APC Anti-pan Cytokeratin antibody [C-11] (ab106166)")
Flow Cytometry (Intracellular) - APC Anti-pan Cytokeratin antibody [C-11] (ab106166)
Flow cytometry analysis (intracellular staining) of cytokeratin expression in HeLa cells using ab106166
![Flow Cytometry (Intracellular) - APC Anti-pan Cytokeratin antibody [C-11] (ab106166), expandable thumbnail](https://content.abcam.com/products/images/apc-pan-cytokeratin-antibody-c-11-ab106166--flow-cytometry-intracellular-img435981.jpg "Flow Cytometry (Intracellular) - APC Anti-pan Cytokeratin antibody [C-11] (ab106166)")
Flow Cytometry (Intracellular) - APC Anti-pan Cytokeratin antibody [C-11] (ab106166)
Separation of HeLa cells stained using ab106166 (concentration in sample 5 µg/ml red-filled) from HeLa cells stained using mouse IgG1 isotype control APC antibody (concentration in sample 5 µg/ml same as Cytokeratins APC concentration black-dashed) in flow cytometry analysis (intracellular staining).
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