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AB270637

APC Anti-PD-L2 antibody [24F.10C12]

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Mouse Monoclonal PD-L2 antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PDCD1LG2.

View Alternative Names

CD273, B7DC, PDCD1L2, PDL2, PDCD1LG2, Programmed cell death 1 ligand 2, PD-1 ligand 2, PD-L2, PDCD1 ligand 2, Programmed death ligand 2, Butyrophilin B7-DC, B7-DC

2 Images
Flow Cytometry - APC Anti-PD-L2 antibody [24F.10C12] (AB270637)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-PD-L2 antibody [24F.10C12] (AB270637)

Flow cytometric analysis of human stimulated monocytes (GM-CSF + IL4) labeling PD-L2 using ab270637. Concentration of 10 μl reagent per million cells in 100μl of cell suspension.

Flow Cytometry - APC Anti-PD-L2 antibody [24F.10C12] (AB270637)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-PD-L2 antibody [24F.10C12] (AB270637)

Flow cytometry analysis of human dentritic cells differentiated upon monocyte stimulation (GM-CSF + IL-4) (red) and non-stimulated lymphocytes cells (black) labeling PD-L2 using ab270637. Concentration of 10 μl reagent/100μl peripheral whole blood. Surface staining.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

24F.10C12

Isotype

IgG2a

Light chain type

kappa

Conjugation

APC

Excitation/Emission

Ex: 650nm, Em: 660nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Recombinant Full Length Protein corresponding to Human PDCD1LG2.

Q9BQ51

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Complementary Products

Assay Kits

AB231928

Human PD-L2 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human PD-L2 ELISA Kit (AB231928)

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Primary Antibodies

AB209959

Alexa Fluor® 488 Anti-PD-L1 antibody [28-8]

RabMAb|Recombinant

Flow Cytometry - Alexa Fluor® 488 Anti-PD-L1 antibody [28-8] (AB209959)

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Primary Antibodies

AB199837

Alexa Fluor® 647 Anti-HLA A antibody [EP1395Y]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-HLA A antibody [EP1395Y] (AB199837)

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  • 1
Primary Antibodies

AB210312

APC Anti-Fas Ligand antibody [NOK-1]

Flow Cytometry - APC Anti-Fas Ligand antibody [NOK-1] (AB210312)

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Primary Antibodies

AB204670

Alexa Fluor® 488 Anti-Fas antibody [EPR5700]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 488 Anti-Fas antibody [EPR5700] (AB204670)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Size-exclusion chromatography
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PD-L2 also known as PDCD1LG2 or B7-DC is a member of the B7 protein family that plays a role in immune system regulation. This protein has a molecular mass of approximately 25 kDa. PD-L2 is expressed in antigen-presenting cells such as dendritic cells and macrophages. Expression is also located in some subsets of T cells and B cells. The PD-L2 can act as a second ligand for the PD-1 receptor which is important in immune checkpoints.
Biological function summary

PD-L2 offers protection to tissues from autoimmunity by regulating T-cell activation and fostering tolerance. By engaging with its receptor PD-1 PD-L2 forms a complex that modulates the immune response to prevent overactivation. This interaction limits the immune system's potential damage to healthy tissues maintaining proper immune function in diverse environments.

Pathways

PD-L2 participates in the immune checkpoint pathways where it works closely with PD-1 to mediate immune responses. PD-L2 forms an important part of the program death-1 (PD-1) pathway which plays a prominent role in downregulating T-cell activity. It relates to proteins such as PD-L1 which also interacts with PD-1 modulating immune tolerance and response to infections or tumors.

PD-L2 involvement has been significant in cancer immunology and autoimmune conditions. Its interaction with PD-1 relates to the suppression of immune responses in tumors contributing to cancer progression. PD-L2's function as an immune checkpoint ligand associates with autoimmune diseases like rheumatoid arthritis where immune regulation goes awry. Both PD-1 and PD-L2 represent potential targets for therapeutic interventions due to their roles in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a critical role in induction and maintenance of immune tolerance to self (PubMed : 11224527, PubMed : 12538684). Acts as a ligand for the inhibitory receptor PDCD1/PD-1, inhibiting T-cell proliferation by blocking cell cycle progression and cytokine production (PubMed : 11224527).
See full target information PDCD1LG2
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Product promise

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