Rabbit Recombinant Monoclonal PTP1B antibody - conjugated to APC.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
PTPN2
PTP1B, PTPN1, Tyrosine-protein phosphatase non-receptor type 1, Protein-tyrosine phosphatase 1B, PTP-1B
Rabbit Recombinant Monoclonal PTP1B antibody - conjugated to APC.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
PTP1B also known as protein tyrosine phosphatase non-receptor type 1 mechanically functions as an important regulator of signaling pathways by removing phosphate groups from tyrosine residues on target proteins. It has an approximate mass of 50 kDa and is widely expressed in various tissues including the liver muscle and both central and peripheral nervous systems. TCPTP another name for this protein has similar enzymatic properties and serves overlapping and distinct functions in cellular regulation.
Protein tyrosine phosphatase 1B (PTP1B) plays a critical role in controlling cell growth differentiation and metabolism. It influences the insulin signaling pathway affecting glucose homeostasis and energy utilization. PTP1B also engages in immune cell signaling and modulation of inflammatory responses. While typically studied independently this phosphatase can also form part of larger molecular complexes that impact broader signaling environments.
Protein tyrosine phosphatase 1B acts as a central node in the insulin and leptin signaling pathways. These pathways significantly influence metabolic processes and energy balance with PTP1B modulating key interactions with insulin receptors and leptin receptors. It closely interacts with proteins such as IRS1 and IRS2 which play substantial roles in transmitting signals downstream of insulin action impacting cellular uptake of glucose and lipid metabolism.
Improper regulation of PTP1B links to type 2 diabetes and obesity due to its involvement in insulin resistance and energy imbalance. Altered PTP1B activity affects insulin receptor function contributing to the pathophysiology of these metabolic disorders. Additionally in relation to obesity PTP1B modulates leptin receptor signaling an important aspect in energy expenditure and weight regulation. These connections make it a target for potential therapeutic interventions focused on metabolic diseases.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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