Rabbit Recombinant Monoclonal RABL3 antibody - conjugated to APC.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
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Required for KRAS signaling regulation and modulation of cell proliferation (PubMed:31406347). Regulator of KRAS prenylation, and probably prenylation of other small GTPases (PubMed:31406347). Required for lymphocyte development and function (By similarity). Not required for myeloid cell development (By similarity).
Rab-like protein 3, RABL3
Rabbit Recombinant Monoclonal RABL3 antibody - conjugated to APC.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA
This conjugated primary antibody is “made to order” and it is released using a quantitative quality control method that ensures binding affinity and labelling efficiency of the conjugate. Via leveraging the power of the Lightning-Link® conjugation technology, Abcam will deliver highly consistent recombinant conjugates in <2 weeks, giving you access to an ever growing portfolio of antibody-label combinations.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
RABL3 also known as Rab-like protein 3 is a member of the Rab-like small GTPase family. It has a molecular mass of approximately 28 kDa. RABL3 plays a central role in cellular trafficking and transport by acting as a molecular switch cycling between an active GTP-bound state and an inactive GDP-bound state. Expression of RABL3 is widespread across various tissues although its exact expression pattern may vary depending on the cell type and physiological condition.
RABL3 functions in the regulation of intracellular signaling pathways. It associates with other molecular partners to influence the dynamics of cargo transport through vesicles. While it is not specifically identified as part of a larger complex its interactions with other small GTPases suggest a collaborative role in vesicle docking and fusion processes. RABL3's function impacts cell communication and signal transduction vital processes in maintaining cellular homeostasis and response to environmental signals.
RABL3 engages in the RAS signaling pathway where it may regulate downstream effects of RAS activation. In particular it can interact with proteins like RAB6 and RABL2 which share similar roles in vesicular trafficking and transport. The RAS signaling pathway's influence in growth and metabolism provides insight into RABL3's potential to modulate signal transduction efficiency and cellular response mechanisms.
Defects in RABL3 are associated with certain forms of cancer and neurodegenerative disorders. Its involvement is particularly noted in its connection to the KRAS protein which is significantly implicated in oncogenic transformations. Alterations in RABL3 expression or function may disrupt normal cellular signaling and transport contributing to disease progression. Understanding these interactions can help target therapeutic strategies for conditions related to these dysregulated pathways.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com