APC Anti-Radixin/RDX antibody [EP1862Y]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Radixin also known as RDX is a member of the ezrin-radixin-moesin (ERM) family of proteins. It weighs approximately 68 kDa and is expressed in a variety of tissues with high levels found in the brain liver and intestines. Radixin functions mechanically by binding to actin filaments and linking them to the plasma membrane. This process is essential for maintaining cell shape and facilitating signal transduction.

Biological function summary

Radixin plays a role in modulating cell surface structure which influences microvilli formation and stability. Radixin serves as a linkage between the actin cytoskeleton and the plasma membrane which helps in forming actin-rich surface structures. It does not function alone; it often acts as part of larger complexes that control cytoskeleton-related activities. Its role in maintaining cellular architecture makes it integral to processes like cell adhesion migration and polarization.

Pathways

Radixin is an important component in signaling pathways that regulate the cytoskeleton and cell membrane interactions. Key pathways include the Rho family of GTPases and the PI3K/Akt pathway. Radixin interacts with these pathways by connecting with proteins such as RhoA which regulates actin dynamics and Akt which influences cell survival and growth. These interactions are important for cellular responses to environmental and internal signals.

Improper function of radixin relates to certain pathological conditions including hepatocellular carcinoma and cholestasis. In hepatocellular carcinoma radixin impacts cell proliferation and migration making it a potential target for cancer therapy. In cholestasis radixin dysfunction has connections with altered bile canalicular structures often interacting with proteins like CFTR. These associations highlight its significance as a potential target for therapeutic strategies aiming to correct cellular structures in these disorders.